Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions

WANG Liang-bin; ZHANG Wei-ning; SHAO Yue; DU Hong-yan; WANG Jin-xi et al.

Volume 16 Issue 4

Jul. 1995

Turn off MathJax

Article Contents

Article Navigation > Zoological Research > 1995 > 16(4): 373-377

WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.

Citation:

WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.

Citation:

PDF( 141 KB)

Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions

Department of Biological Science and Technology,Nanjing University,Nanjing 210093

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 1995-11-22

Abstract

Abstract

In this experiment,the synaptosomal free calcium concentration and synaptosomal membrane protein-bound Ca[2+] in various brain regions were measured by using fluorescence indicator Fura-2/AM and Tb[3+] respectively.Compared with that of 3-month-old rats,the synaptosomal free calcium concentration significantly increased in hippocampus,cerebral cortex and hypothalamus of 26-month-old rats.Moreover,the synaptosomal membrane protein-bound Ca[2+] obviously increased in hippocampus and cerebellum while in the other brain areas examined (cerebral cortex,hypothalamus) decreased significantly.These suggest that the perturbation of normal Ca[2+] homeostasis appears to be an important factor correlated with aging.
- Age,
- Rat brain,
- Synaptosome,
- Ca[2+],