Influence of Dorsal Raphe Nucleus on Electrical Activity of the Cerebellar Purkinje Cell in The Cat

In thiopentone-anaesthetized and curarized cats we found that dorsal raphe (DR) stimulation could elicit long latency inhibitory,and in fewer cases,excitatory responses in cerebellar Purkinje cells (PC),and the peripheral inputs elicited by passive forepaw flexion-extension movements may enhance or reduce the response of PCs to DR stimulation.The results suggest that the raphe-cerebellar serotonergic fiber may modulate PCs activity and interact with the peripheral input.