Volume 33 Issue 5
Sep.  2012
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LI Pei-Lu, CHEN Qian-Qian, ZHANG Chi-Yu. SAMHD1— A HIV-1 restriction factor derived from myeloid lineage monocytes. Zoological Research, 2012, 33(5): 537-541. doi: 10.3724/SP.J.1141.2012.05537
Citation: LI Pei-Lu, CHEN Qian-Qian, ZHANG Chi-Yu. SAMHD1— A HIV-1 restriction factor derived from myeloid lineage monocytes. Zoological Research, 2012, 33(5): 537-541. doi: 10.3724/SP.J.1141.2012.05537

SAMHD1— A HIV-1 restriction factor derived from myeloid lineage monocytes

doi: 10.3724/SP.J.1141.2012.05537
  • Received Date: 2012-04-28
  • Rev Recd Date: 2012-08-27
  • Publish Date: 2012-10-10
  • HIV-1 restriction factors have became one of the hottest fields of AIDS researches. In 2011, SAMHD1 was demonstrated to be a novel HIV-1 restriction factor, adding to a list of HIV-1 restriction factors that include APOBEC3G, TRIM5a and Tetherin. SAMHD1 is highly expressed in myeloid-lineage monocytes, such as macrophages and dendritic cells. In this paper, we review the current research progress on the structure of SAMHD1, its antiviral mechanism, interaction with the lentivirus Vpx, and evolution. The identification of SAMHD1 opens the door towards understanding the role of SAMHD1 in lentiviral pathogenesis.
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