Aging affects early stage direction selectivity of MT cells in rhesus monkeys

LIANG Zhen; CHEN Yue-Ming; MENG Xue; WANG Yi; ZHOU Bao-Zhuo; XIE Ying-Ying; HE Wen-Sheng

doi:10.3724/SP.J.1141.2012.05498

Volume 33 Issue 5

Sep. 2012

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Article Navigation > Zoological Research > 2012 > 33(5): 498-502

LIANG Zhen, CHEN Yue-Ming, MENG Xue, WANG Yi, ZHOU Bao-Zhuo, XIE Ying-Ying, HE Wen-Sheng. Aging affects early stage direction selectivity of MT cells in rhesus monkeys. Zoological Research, 2012, 33(5): 498-502. doi: 10.3724/SP.J.1141.2012.05498

Citation:

LIANG Zhen, CHEN Yue-Ming, MENG Xue, WANG Yi, ZHOU Bao-Zhuo, XIE Ying-Ying, HE Wen-Sheng. Aging affects early stage direction selectivity of MT cells in rhesus monkeys. Zoological Research, 2012, 33(5): 498-502. doi: 10.3724/SP.J.1141.2012.05498

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Aging affects early stage direction selectivity of MT cells in rhesus monkeys

doi: 10.3724/SP.J.1141.2012.05498

1.
Department of Bio-Medical Engineering, Anhui Medical University, Hefei Anhui 230032, China;
2.
Vision Research Laboratory, School of Life Science, University of Science and Technology of China, Hefei Anhui 230027, China

Received Date: 2012-06-11
Rev Recd Date: 2012-07-10
Publish Date: 2012-10-10

Abstract

Abstract

The middle temporal area (MT/V5) plays an important role in motion processing. Neurons in this area have a strongly selective response to the moving direction of objects and as such, the selectivity of MT neurons was proposed to be a neural mechanism for the perception of motion. Our previous studies have found degradation in direction selectivity of MT neurons in old monkeys, but this direction selectivity was calculated during the whole response time and the results were not able to uncover the mechanism of motion perception over a time course. Furthermore, experiments have found that direction selectivity was enhanced by attention at a later stage. Therefore, the response should be excluded in experiments with anesthesia. To further characterize the neural mechanism over a time course, we investigated the age-related changes of direction selectivity in the early stage by comparing the proportions of direction selective MT cells in old and young macaque monkeys using in vivo single-cell recording techniques. Our results show that the proportion of early-stage-direction-selective cells is lower in old monkeys than in young monkeys, and that the early stage direction bias (esDB) of old MT cells decreased relative to young MT cells. Furthermore, the proportion of MT cells having strong early stage direction selectivity in old monkeys was decreased. Accordingly, the functional degradation in the early stage of MT cells may mediate perceptual declines of old primates in visual motion tasks.
- Early stage direction selectivity,
- Middle temporal area,
- Aging

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References(35)

References

[1]	Albright TD. 1984. Direction and orientation selectivity of neurons in visual area MT of the macaque [J]. J Neurophysiol, 52(6): 1106-1130.
[2]	Ball K, Sekuler R. 1986. Improving visual perception in older observers [J]. J Gerontol, 41(2): 176-182.
[3]	Bergen JR, Julesz B. 1983. Parallel versus serial processing in rapid pattern discrimination [J]. Nature, 303(5919): 696-698.
[4]	Betts LR, Taylor CP, Sekuler AB, Bennett PJ. 2005. Aging reduces center-surround antagonism in visual motion processing [J]. Neuron, 45(3): 361-366.
[5]	Britten KH, Shadlen MN, Newsome WT, Movshon JA. 1992. The analysis of visual motion: a comparison of neuronal and psychophysical performance [J]. J Neurosci, 12(12): 4745-4765.
[6]	Butler KM, Zacks RT. 2006. Age deficits in the control of prepotent responses: evidence for an inhibitory decline [J]. Psychol Aging, 21(3): 638-643.
[7]	Cavanagh P, Arguin M, Treisman A. 1990. Effect of surface medium on visual search for orientation and size features [J]. J Exp Psychol Hum Percept Perform, 16(3): 479-491.
[8]	Duan H, Wearne SL, Rocher AB, Macedo A, Morrison JH, Hof PR. 2003. Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys [J]. Cereb Cortex, 13(9): 950-961.
[9]	Habak C, Faubert J. 2000. Larger effect of aging on the perception of higher-order stimuli [J]. Vision Res, 40(8): 943-950.
[10]	Leventhal AG, Thompson KG, Liu D, Zhou Y, Ault SJ. 1995. Concomitant sensitivity to orientation, direction, and color of cells in layers 2, 3, and 4 of monkey striate cortex [J]. J Neurosci, 15(3 Pt 1): 1808-1818.
[11]	Leventhal AG, Wang YC, Pu ML, Zhou YF, Ma YY. 2003. GABA and its agonists improved visual cortical function in senescent monkeys [J]. Science, 300(5620): 812-815.
[12]	Liang Z, Yang Y, Li GX, Zhang J, Wang YC, Zhou YF, Leventhal AG. 2010. Aging affects the direction selectivity of MT cells in rhesus monkeys [J]. Neurobiol Aging, 31(5): 863-873.
[13]	Martinez-Trujillo JC, Treue S. 2004. Feature-based attention increases the selectivity of population responses in primate visual cortex [J]. Curr Biol, 14(9): 744-751.
[14]	Morrison JH, Hof PR. 1997. Life and death of neurons in the aging brain [J]. Science, 278(5337): 412-419.
[15]	Morrison JH, Hof PR. 2007. Life and death of neurons in the aging cerebral cortex [J]. Int Rev Neurobiol, 81: 41-57.
[16]	Movshon JA, Adelson EH, Gizzi MS, Newsome WT. 1986. The analysis of moving visual patterns [J]. Exp Brain Res, 54(Suppl 2): 117-151.
[17]	Newsome WT, Pare EB. 1988. A selective impairment of motion perception following lesions of the middle temporal visual area (MT) [J]. J Neurosci, 8(6): 2201-2211.
[18]	Norman J F, Ross HE, Hawkes LM, Long JR. 2003. Aging and the perception of speed [J]. Perception, 32(1): 85-96.
[19]	Peters A, Morrison JH, Rosene DL, Hyman BT. 1998. Feature article: are neurons lost from the primate cerebral cortex during normal aging? [J]. Cereb Cortex, 8(4): 295-300.
[20]	Peters A, Rosene DL, Moss MB, Kemper TL, Abraham CR, Tigges J, Albert MS. 1996. Neurobiological bases of age-related cognitive decline in the rhesus monkey [J]. J Neuropathol Exp Neurol, 55(8): 861-874.
[21]	Roelfsema PR, Tolboom M, Khayat PS. 2007. Different processing phases for features, figures, and selective attention in the primary visual cortex [J]. Neuron, 56(5): 785-792.
[22]	Schmolesky MT, Wang Y, Pu M, Leventhal AG., 2000. Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys [J]. Nat Neurosci, 3, 384–390.
[23]	Snowden RJ, Kavanagh E. 2006. Motion perception in the ageing visual system: minimum motion, motion coherence, and speed discrimination thresholds [J]. Perception, 35(1): 9-24.
[24]	Spear PD. 1993. Neural bases of visual deficits during aging [J]. Vision Res, 33(18): 2589-2609.
[25]	Spear PD, Moore RJ, Kim CB, Xue JT, Tumosa N. 1994. Effects of aging on the primate visual system: spatial and temporal processing by lateral geniculate neurons in young adult and old rhesus monkeys [J]. J Neurophysiol, 72(1): 402-420.
[26]	Thiele A, Distler C, Korbmacher H, Hoffmann KP. 2004. Contribution of inhibitory mechanisms to direction selectivity and response normalization in macaque middle temporal area [J]. Proc Natl Acad Sci USA, 101(26): 9810-9815.
[27]	Tigges J, Gordon TP, McClure HM, Hall EC, Peters A. 1988. Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center [J]. Am J Primatol, 15(3): 263-273.
[28]	Tran DB, Silverman SE, Zimmerman K, Feldon SE. 1998. Age-related deterioration of motion perception and detection [J]. Graefes Arch Clin Exp Ophthalmol, 236(4): 269-273.
[29]	Treisman AM, Gelade G. 1980. A feature-integration theory of attention [J]. Cogn Psychol, 12(1): 97-136.
[30]	Trick GL, Silverman SE. 1991. Visual sensitivity to motion: age-related changes and deficits in senile dementia of the Alzheimer type [J]. Neurology, 41(9): 1437-1440.
[31]	Willis A, Anderson SJ. 2000. Effects of glaucoma and aging on photopic and scotopic motion perception [J]. Invest Ophthalmol Vis Sci, 41(1): 325-335.
[32]	Wist ER, Schrauf M, Ehrenstein WH. 2000. Dynamic vision based on motion- contrast: changes with age in adults [J]. Exp Brain Res, 134(3): 295-300.
[33]	Wong TP. 2002. Aging of the cerebral cortex [J]. McGill J Med, 6: 104-113.
[34]	Yang Y, Zhang J, Liang Z, Li GX, Wang YC, Ma YY, Zhou YF, Leventhal AG. 2009. Aging affects the neural representation of speed in Macaque area MT [J]. Cereb Cortex, 19(9): 1957-1967.
[35]	Yu S, Wang Y, Li X, Zhou Y, Leventhal AG. 2006. Functional degradation of extrastriate visual cortex in senescent rhesus monkeys [J]. Neuroscience, 140(3): 1023-1029.