Volume 32 Issue 6
Nov.  2011
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GUO Xiang-Yu, JIN Li-Fang, JI Shao-Hui, JI Wei-Zhi. Rhesus monkey (Macaca mulatta) muller cells exhibit retinal stem/progenitor cell features in vitro. Zoological Research, 2011, 32(6): 611-616. doi: 10.3724/SP.J.1141.2011.06616
Citation: GUO Xiang-Yu, JIN Li-Fang, JI Shao-Hui, JI Wei-Zhi. Rhesus monkey (Macaca mulatta) muller cells exhibit retinal stem/progenitor cell features in vitro. Zoological Research, 2011, 32(6): 611-616. doi: 10.3724/SP.J.1141.2011.06616

Rhesus monkey (Macaca mulatta) muller cells exhibit retinal stem/progenitor cell features in vitro

doi: 10.3724/SP.J.1141.2011.06616
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  • Author Bio:

    GUO Xiang-Yu

  • Corresponding author: JI Wei-Zhi
  • Received Date: 2011-05-10
  • Rev Recd Date: 2011-10-20
  • Publish Date: 2011-12-22
  • Recent evidences indicate that retinal muller cells exhibit retinal progenitor characteristics under certain condition in chick, rat and human. However, there is no report on nonhuman primate, a close relative to human. In this study, we first established a muller cell line of rhesus monkey expressing GS, vimentin, CRALBP, EGFR, barely GFAP, which resemble the expression profile of human muller cells, differ from that of rodent. Expression of pax6, nestin, sox2, otx2, six6, and six3 was detected after one week culture in neural stem cell medium. Further culture with retinoic acid induced some cells differentiate toward neuron. These results suggest that primate muller cell is capable of dedifferentiating to retinal progenitors, which may serve as a potential cell source for cell therapy to treat retinal degenerative diseases.
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