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Volume 29 Issue 5
Sep.  2008
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Article Navigation >  Zoological Research  > 2008  >  29(5): 493-502
LIU Shu-bai, HE Ying-ying, QIAN Jinqiao, ZHANG Yun. CAT, Induced Isolated Rabbit Thoracic Aortic Rings Sustained Contraction in Endothelial-dependent Manner. Zoological Research, 2008, 29(5): 493-502. doi: 10.3724/SP.J.1141.2008.05493
Citation: LIU Shu-bai, HE Ying-ying, QIAN Jinqiao, ZHANG Yun. CAT, Induced Isolated Rabbit Thoracic Aortic Rings Sustained Contraction in Endothelial-dependent Manner
. Zoological Research, 2008, 29(5): 493-502. doi: 10.3724/SP.J.1141.2008.05493
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CAT, Induced Isolated Rabbit Thoracic Aortic Rings Sustained Contraction in Endothelial-dependent Manner

doi: 10.3724/SP.J.1141.2008.05493
  • 1.

    Biotoxin Units, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China; 2. Department of Anesthesiology, the First Affiliated Hospital of Kunming Medical College, Kunming Yunnan 650032, China; 3. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

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  • Corresponding author: ZHANG Yun
  • Received Date: 2008-06-16
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2008-10-22
    Abstract
  • In vertebrates, non-lens bg-crystallins are widely expressed in various tissues and their functions are not well known. The molecular mechanisms of trefoil factors (TFFs), which involved in mucosal healing and tumorigenesis, have remained elusive. bg-CAT is a novel multifunctional protein complex of non-lens bg-crystallin and trefoil factor from frog skin secretions. Here we report that bg-CAT could induce sustained contraction of isolated rabbit aortic rings in dosage (2-35 nmol/L) and endothelium dependent manners (P<0.01). In addition, in situ immunofluorescence indicated that positive TNF-a signals were mainly detected at the endothelial cell layer of bg-CAT (25 nmol/L) treated rings. Furthermore，bg-CAT induced primary cultured rabbit thoracic aortic endothelial cells (RAECs) rapidly to release TNF-a. After bg-CAT (25 nmol/L) treated for 10 and 30 min, the levels of the endothelial cells released TNF-a were 34.17 Keywords:
  • a')">Tumor necrosis factor-a, 
  • Trefoil factor, 
  • Non-lens bg-crystallin, 
  • Endothelium-dependent aorta vasoconstriction, 
  • bg-CAT
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