Dan Yang, Bin-Bin Nie, Jingang He, Zongqiang Lv, Fengfeng Mo, Siyi Ouyang , Jie Wang, Juxiang Chen, Tao Tao. 2024. Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury. Zoological Research. DOI: 10.24272/j.issn.2095-8137.2023.323
Citation: Dan Yang, Bin-Bin Nie, Jingang He, Zongqiang Lv, Fengfeng Mo, Siyi Ouyang , Jie Wang, Juxiang Chen, Tao Tao. 2024. Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury. Zoological Research. DOI: 10.24272/j.issn.2095-8137.2023.323

Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

  • Mild traumatic brain injury (mTBI) induced posttraumatic headache (PTH) is a pressing public health concern that continues to be a leading cause of disability worldwide. PTH is often accompanied by neurological disorders, however, the exact underlying mechanism remains largely unknown. Identifying the potential biomarkers may prompt diagnosis and develop effective treatments for mTBI induced PTH. Here, a mouse model of mTBI-induced PTH was established, and a series of technologies were employed to investigate the effects on cerebral structure and functions during the short-term recovery periods. Results indicated that mTBI induced PTH exhibited balance deficits during early stage of post injury. The metabolic kinetics studies revealed that variations in neurotransmitters were most prominent in the regions of cerebellum (CE), temporal lobe/cortex, and hippocampus in the early stages of PTH. Additionally, variations of functional activities and connectivity were further detected in the brain in the early stage of PTH, particularly in CE and temporal cortex. These findings suggested that CE and temporal cortex play central roles in the investigation of the mechanism of PTH. Moreover, the results suggested that GABA and glutamate might serve as potential diagnostic or prognostic biomarkers for PTH. Future studies should investigate the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex, and these two regions can be utilized as the targets for the non-invasive stimulation treatment technologies in the future clinical treatment.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return