Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms

Xiao-Wen Zhang; Xiang-Xing Zhu; Dong-Sheng Tang; Jia-Hong Lu

doi:10.24272/j.issn.2095-8137.2023.294

Volume 44 Issue 6

Nov. 2023

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Xiao-Wen Zhang, Xiang-Xing Zhu, Dong-Sheng Tang, Jia-Hong Lu. Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms. Zoological Research, 2023, 44(6): 1132-1145. doi: 10.24272/j.issn.2095-8137.2023.294

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Xiao-Wen Zhang, Xiang-Xing Zhu, Dong-Sheng Tang, Jia-Hong Lu. Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms. Zoological Research, 2023, 44(6): 1132-1145. doi: 10.24272/j.issn.2095-8137.2023.294

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Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms

doi: 10.24272/j.issn.2095-8137.2023.294

1.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 99078, China
2.
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Gene Editing Technology Center of Guangdong Province, Foshan University, Foshan, Guangdong 528225, China

The authors declare that they have no competing interests.
X.W.Z. wrote the first draft of the manuscript. J.H.L., X.X.Z., and D.S.T. contributed to the conception, design, and revision of the manuscript. All authors read and approved the final version of the manuscript.

Funds: This study was supported by the National Natural Science Foundation of China (82271455), Guangdong Basic and Applied Basic Research Foundation (2022A1515012416), Science and Technology Development Fund, Macau SAR (0128/2019/A3, 0025/2022/A1), Shenzhen Fundamental Research Program (SGDX20210823103804030), and University of Macau Grants (MYRG2022-00094-ICMS) awarded to J.H.L., and partially supported by the National Key R&D Program of China (2021YFA0805901), National Natural Science Foundation of China (82070199), and Guangdong Basic and Applied Basic Research Foundation (2021A1515220078) awarded to D.S.T.

More Information

Corresponding author: E-mail: tangdsh@163.com; jiahonglu@um.edu.mo
Received Date: 2023-10-14
Accepted Date: 2023-10-30

Published Online: 2023-10-31

Publish Date: 2023-11-18

Abstract

Abstract

Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss. Emerging evidence suggests that autophagy plays an important role in the pathogenesis of AD through the regulation of amyloid-beta (Aβ) and tau metabolism, and that autophagy dysfunction exacerbates amyloidosis and tau pathology. Therefore, targeting autophagy may be an effective approach for the treatment of AD. Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases. This review aims to summarize the pathological alterations in autophagy in representative AD animal models and to present recent studies on newly discovered autophagy-stimulating interventions in animal AD models. Finally, the opportunities, difficulties, and future directions of autophagy targeting in AD therapy are discussed.
- Alzheimer’s disease,
- Aβ metabolism,
- Tau pathology,
- Autophagy,
- Animal models

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References(147)

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