Volume 44 Issue 5
Sep.  2023
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Jia-Jia Chen, Kai Lei. The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration. Zoological Research, 2023, 44(5): 981-992. doi: 10.24272/j.issn.2095-8137.2023.044
Citation: Jia-Jia Chen, Kai Lei. The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration. Zoological Research, 2023, 44(5): 981-992. doi: 10.24272/j.issn.2095-8137.2023.044

The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

doi: 10.24272/j.issn.2095-8137.2023.044
The authors declare that they have no competing interests.
J.J.C. and K.L. wrote the manuscript and constructed the figures. All authors read and approved the final version of the manuscript.
Funds:  This work was supported by the Westlake Education Foundation and National Natural Science Foundation of China (32122032 and 31970750 to K.L.)
More Information
  • Corresponding author: E-mail: leikai@westlake.edu.cn
  • Received Date: 2023-06-02
  • Accepted Date: 2023-06-02
  • Published Online: 2023-09-12
  • Publish Date: 2023-09-18
  • Planarians represent the most primitive bilateral triploblastic animals. Most planarian species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration of their cephalic ganglion after complete excision. Given their robust whole-body regeneration capacity, planarians have been model organisms in regenerative research for more than 240 years. Advancements in research tools and techniques have progressively elucidated the mechanisms underlying planarian regeneration. Accurate cell-cell communication is recognized as a fundamental requirement for regeneration. In recent decades, mechanisms associated with such communication have been revealed at the cellular level. Notably, stem cells (neoblasts) have been identified as the source of all new cells during planarian homeostasis and regeneration. The interplay between neoblasts and somatic cells affects the identities and proportions of various tissues during homeostasis and regeneration. Here, this review outlines key discoveries regarding communication between stem cell compartments and other cell types in planarians, as well as the impact of communication on planarian regeneration. Additionally, this review discusses the challenges and potential directions of future planarian research, emphasizing the sustained impact of this field on our understanding of animal regeneration.

  • The authors declare that they have no competing interests.
    J.J.C. and K.L. wrote the manuscript and constructed the figures. All authors read and approved the final version of the manuscript.
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