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Volume 44 Issue 3
May  2023
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Article Navigation >  Zoological Research  > 2023  >  44(3): 525-542
Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei. Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models. Zoological Research, 2023, 44(3): 525-542. doi: 10.24272/j.issn.2095-8137.2023.025
Citation: Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei. Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models. Zoological Research, 2023, 44(3): 525-542. doi: 10.24272/j.issn.2095-8137.2023.025
shu

Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models

doi: 10.24272/j.issn.2095-8137.2023.025
  • 1.

    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Wuhan, Hubei 430071, China

  • 2.

    School of Medicine, Shanghai University, Shanghai 200444, China

  • 3.

    State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China

  • 4.

    Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China

  • 5.

    School of Life Sciences, Shanghai University, Shanghai 200444, China

#Authors contributed equally to this work
Funds:  This work was supported by the National Natural Science Foundation of China (81825011, 81930038, 81961160738), Program of Shanghai Academic/Technology Research Leader (22XD1400800), and Strategic Priority Research Program of the Chinese Academy of Sciences (XDB19030200)
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    Abstract
  • Viral infections have led to many public health crises and pandemics in the last few centuries. Neurotropic virus infection-induced viral encephalitis (VE), especially the symptomatic inflammation of the meninges and brain parenchyma, has attracted growing attention due to its high mortality and disability rates. Understanding the infectious routes of neurotropic viruses and the mechanism underlying the host immune response is critical to reduce viral spread and improve antiviral therapy outcomes. In this review, we summarize the common categories of neurotropic viruses, viral transmission routes in the body, host immune responses, and experimental animal models used for VE study to gain a deeper understanding of recent progress in the pathogenic and immunological mechanisms under neurotropic viral infection. This review should provide valuable resources and perspectives on how to cope with pandemic infections.
    • #Authors contributed equally to this work
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