Volume 44 Issue 4
Jul.  2023
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Qing Wang, Xiang Zhang, Yu-Jie Guo, Ya-Yan Pang, Jun-Jie Li, Yan-Li Zhao, Jun-Fen Wei, Bai-Ting Zhu, Jing-Xiang Tang, Yang-Yang Jiang, Jie Meng, Ji-Rong Yue, Peng Lei. Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss. Zoological Research, 2023, 44(4): 712-724. doi: 10.24272/j.issn.2095-8137.2022.473
Citation: Qing Wang, Xiang Zhang, Yu-Jie Guo, Ya-Yan Pang, Jun-Jie Li, Yan-Li Zhao, Jun-Fen Wei, Bai-Ting Zhu, Jing-Xiang Tang, Yang-Yang Jiang, Jie Meng, Ji-Rong Yue, Peng Lei. Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss. Zoological Research, 2023, 44(4): 712-724. doi: 10.24272/j.issn.2095-8137.2022.473

Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss

doi: 10.24272/j.issn.2095-8137.2022.473
Supplementary data to this article can be found online.
The authors declare that they have no competing interests.
P.L. conceived of the study. P.L. and J.R.Y. raised funds for the study. Q.W. and X.Z. designed and performed the experiments with supervision from P.L. and J.R.Y. Y.Y.P. and J.J.L. performed the electrophysiological experiments, J.F.W., B.T.Z., and J.X.T. performed immunohistochemical analysis with supervision from Y.J.G. and P.L. Y.L.Z., Y.Y.J., and J.M. performed animal surgeries with Q.W. Q.W., J.R.Y., and P.L. integrated the data and wrote the draft manuscript. All authors read and approved the final version of the manuscript.
#Authors contributed equally to this work
Funds:  This work was supported by the National Natural Science Foundation of China (82071191, 82001129), Natural Science Foundation of Sichuan Province (2022NSFSC1509), National Clinical Research Center for Geriatrics of West China Hospital (Z2021LC001), and West China Hospital 1.3.5 Project for Disciplines of Excellence (ZYYC20009)
More Information
  • Corresponding author: E-mail: yuejirong11@hotmail.com; peng.lei@scu.edu.cn
  • Received Date: 2023-03-05
  • Accepted Date: 2023-06-05
  • Published Online: 2023-06-12
  • Publish Date: 2023-07-18
  • Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia. However, given its inherent complexity, few animal models of delirium have been established and the mechanism underlying the onset of delirium remains elusive. Here, we conducted a comparison of three mouse models of delirium induced by clinically relevant risk factors, including anesthesia with surgery (AS), systemic inflammation, and neurotransmission modulation. We found that both bacterial lipopolysaccharide (LPS) and cholinergic receptor antagonist scopolamine (Scop) induction reduced neuronal activities in the delirium-related brain network, with the latter presenting a similar pattern of reduction as found in delirium patients. Consistently, Scop injection resulted in reversible cognitive impairment with hyperactive behavior. No loss of cholinergic neurons was found with treatment, but hippocampal synaptic functions were affected. These findings provide further clues regarding the mechanism underlying delirium onset and demonstrate the successful application of the Scop injection model in mimicking delirium-like phenotypes in mice.
  • Supplementary data to this article can be found online.
    The authors declare that they have no competing interests.
    P.L. conceived of the study. P.L. and J.R.Y. raised funds for the study. Q.W. and X.Z. designed and performed the experiments with supervision from P.L. and J.R.Y. Y.Y.P. and J.J.L. performed the electrophysiological experiments, J.F.W., B.T.Z., and J.X.T. performed immunohistochemical analysis with supervision from Y.J.G. and P.L. Y.L.Z., Y.Y.J., and J.M. performed animal surgeries with Q.W. Q.W., J.R.Y., and P.L. integrated the data and wrote the draft manuscript. All authors read and approved the final version of the manuscript.
    #Authors contributed equally to this work
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