Effects of gradient high-field static magnetic fields on diabetic mice

Biao Yu; Chao Song; Chuan-Lin Feng; Jing Zhang; Ying Wang; Yi-Ming Zhu; Lei Zhang; Xin-Miao Ji; Xiao-Fei Tian; Guo-Feng Cheng; Wei-Li Chen; Vitalii Zablotskii; Hua Wang; Xin Zhang

doi:10.24272/j.issn.2095-8137.2022.460

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Biao Yu, Chao Song, Chuan-Lin Feng, Jing Zhang, Ying Wang, Yi-Ming Zhu, Lei Zhang, Xin-Miao Ji, Xiao-Fei Tian, Guo-Feng Cheng, Wei-Li Chen, Vitalii Zablotskii, Hua Wang, Xin Zhang. Effects of gradient high-field static magnetic fields on diabetic mice. Zoological Research, 2023, 44(2): 249-258. doi: 10.24272/j.issn.2095-8137.2022.460

Citation:

Biao Yu, Chao Song, Chuan-Lin Feng, Jing Zhang, Ying Wang, Yi-Ming Zhu, Lei Zhang, Xin-Miao Ji, Xiao-Fei Tian, Guo-Feng Cheng, Wei-Li Chen, Vitalii Zablotskii, Hua Wang, Xin Zhang. Effects of gradient high-field static magnetic fields on diabetic mice. Zoological Research, 2023, 44(2): 249-258. doi: 10.24272/j.issn.2095-8137.2022.460

Citation:

Biao Yu, Chao Song, Chuan-Lin Feng, Jing Zhang, Ying Wang, Yi-Ming Zhu, Lei Zhang, Xin-Miao Ji, Xiao-Fei Tian, Guo-Feng Cheng, Wei-Li Chen, Vitalii Zablotskii, Hua Wang, Xin Zhang. Effects of gradient high-field static magnetic fields on diabetic mice. Zoological Research, 2023, 44(2): 249-258. doi: 10.24272/j.issn.2095-8137.2022.460

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Effects of gradient high-field static magnetic fields on diabetic mice

doi: 10.24272/j.issn.2095-8137.2022.460

Biao Yu¹,
Chao Song¹,
Chuan-Lin Feng^{1, 2},
Jing Zhang^{1, 2},
Ying Wang^{1, 2},
Yi-Ming Zhu³,
Lei Zhang¹,
Xin-Miao Ji¹,
Xiao-Fei Tian³,
Guo-Feng Cheng^{1, 2},
Wei-Li Chen³,
Vitalii Zablotskii^{4, 6},
Hua Wang⁵,
Xin Zhang^{1, 2, 3, 6
,
,}

1.
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China
2.
Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, Anhui 230026, China
3.
Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, China
4.
Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic
5.
Department of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
6.
International Magnetobiology Frontier Research Center, Science Island, Hefei, Anhui 230031, China

Supplementary data to this article can be found online.
The authors declare that they have no competing interests.
X.Z.: Conceptualization, methodology, supervision, writing–original draft, writing–review & editing. B.Y.: Conceptualization, formal analysis, investigation, methodology, software, visualization, writing–original draft, writing–review & editing. C.S., C.L.F., J.Z., Y.M.Z., Y.W., L.Z., X.M.J., X.F.T., G.F.C., and W.L.C.: Methodology, resources, writing–review & editing. V.Z. and H.W.: Resources, data curation, investigation, writing–review & editing. All authors read and approved the final version of the manuscript.

Funds: This work was supported by the National Natural Science Foundation of China (U21A20148, 31900506, 52007185), International Partnership Program of the Chinese Academy of Sciences (116134KYSB20210052), Heye Health Technology Chong Ming Project (HYCMP2021010), CAS President’s International Fellowship Initiative Grant (2022VMA0009), and CASHIPS Director’s Fund (BJPY2021A06, 2021YZGH04, YZJJ2020QN26, YZJJZX202014, YZJJ2021QN32, YZJJ2023QN43)

More Information

Corresponding author: E-mail: xinzhang@hmfl.ac.cn
Received Date: 2022-12-09
Accepted Date: 2023-01-11

Published Online: 2023-01-13

Abstract

Abstract

Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mM), the >10 T/m gradient high SMFs increased malondialdehyde (P<0.01) and decreased superoxide dismutase (P<0.05). However, in the severe T1D mice (blood glucose ≥30.0 mM), the >10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate. In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation. Therefore, this study showed that prolonged exposure to high-field (1.0–8.6 T) >10 T/m gradient SMFs (35–1 380 times higher than that of current clinical MRI) can have negative effects on diabetic mice, especially mice with severe T1D, whereas 9.4 T high SMFs at 0–10 T/m did not produce the same effects, providing important information for the future development and clinical application of SMFs, especially high-field MRI.
- Type 2 diabetes,
- Type 1 diabetes,
- Magnetic resonance imaging (MRI),
- Gradient static magnetic field,
- Quasi-uniform static magnetic field

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References(37)

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