Volume 44 Issue 2
Mar.  2023
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Yan Zhao, Chang-Le Wang, Zhi-Yun Gao, Hong-Xiu Qiao, Wei-Jie Wang, Xin-Yan Liu, Xia Chuai. Ferrets: A powerful model of SARS-CoV-2. Zoological Research, 2023, 44(2): 323-330. doi: 10.24272/j.issn.2095-8137.2022.351
Citation: Yan Zhao, Chang-Le Wang, Zhi-Yun Gao, Hong-Xiu Qiao, Wei-Jie Wang, Xin-Yan Liu, Xia Chuai. Ferrets: A powerful model of SARS-CoV-2. Zoological Research, 2023, 44(2): 323-330. doi: 10.24272/j.issn.2095-8137.2022.351

Ferrets: A powerful model of SARS-CoV-2

doi: 10.24272/j.issn.2095-8137.2022.351
#Authors contributed equally to this work
Funds:  This work was supported by the S&T Program of Hebei (20277705D and 20372601D), Natural Science Foundation of Hebei Province, China (H2020206352), Science and Technology Project of Hebei Education Department (QN2018150), Hebei Medical Science Research Project (20220973), and Chinese Medicine Research Program of Hebei Province (2021119)
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  • Corresponding author: E-mail: chuaixiahb@126.com
  • Received Date: 2022-12-13
  • Accepted Date: 2023-02-16
  • Published Online: 2023-02-17
  • Publish Date: 2023-03-18
  • The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent years not only caused a global pandemic but resulted in enormous social, economic, and health burdens worldwide. Despite considerable efforts to combat coronavirus disease 2019 (COVID-19), various SARS-CoV-2 variants have emerged, and their underlying mechanisms of pathogenicity remain largely unknown. Furthermore, effective therapeutic drugs are still under development. Thus, an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections. Currently, several animal models, including mice, hamsters, ferrets, and non-human primates (NHPs), have been established to study COVID-19. Among them, ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study. Here, we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis, therapeutic agents, and vaccines, and provide a perspective on the role of these models in preventing COVID-19 spread.
  • #Authors contributed equally to this work
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