Volume 43 Issue 6
Nov.  2022
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Article Contents
Feng-Juan Tian, Jing Li, Wen-Li Liu, Yu-Jie Liu, Yun-Jia Hu, Qi-Hang Tu, Yang Li, Yu Bai, Mang Shi, Teng-Cheng Que, Yan-Ling Hu, Yi-Gang Tong. Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses. Zoological Research, 2022, 43(6): 977-988. doi: 10.24272/j.issn.2095-8137.2022.246
Citation: Feng-Juan Tian, Jing Li, Wen-Li Liu, Yu-Jie Liu, Yun-Jia Hu, Qi-Hang Tu, Yang Li, Yu Bai, Mang Shi, Teng-Cheng Que, Yan-Ling Hu, Yi-Gang Tong. Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses. Zoological Research, 2022, 43(6): 977-988. doi: 10.24272/j.issn.2095-8137.2022.246

Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses

doi: 10.24272/j.issn.2095-8137.2022.246
The data that support our findings were deposited in the NCBI database under BioProjectID PRJNA881017, as well as the Genome Sequence Archive (GSA) under accession no. PRJCA010128, and the Science Data Bank under DOI:10.57760/sciencedb.j00139.00041. The consensus sequences in this study were deposited in GenBank under accession numbers OP474153–OP474178 and in the NGDC Genome Warehouse (GWH) (https://ngdc.cncb.ac.cn/gwh/) under accession numbers GWHBJSI01000000–GWHBJTI01000000 (Supplementary Table S2).
Supplementary data to this article can be found online.
The authors declare that they have no competing interests.
Y.G.T., M.S., T.C.Q., and Y.L.H. designed and supervised the research. T.C.Q. collected the samples. W.L.L., Y.J.L., Y.J.H., Q.H.T., Y.L., and Y.B. processed the samples. F.J.T. and J.L. performed data analysis, genome assembly, and phylogenetic analysis and contributed to data interpretation and wrote the paper. Y.G.T., M.S., T.C.Q., and Y.L.H. edited the paper. All authors read and approved the final version of the manuscript.
#Authors contributed equally to this work
Funds:  This study was supported by the State Key Research Development Program of China (2019YFC1200500, 2019YFC1200502), National Key Research and Development Program of China (2018YFA0903000, 2020YFC2005405, 2020YFA0712100, 2020YFC0840805, 2021YFC0863400) and Key Project of Beijing University of Chemical Technology (XK1803-06)
More Information
  • Previous studies have identified multiple viruses in dead or severely diseased pangolins, but descriptions of the virome in healthy pangolins are lacking. This poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with breeders. In this study, we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropod-associated viruses belonging to 11 families and vertebrate viruses belonging to eight families, including those with pathogenic potential in humans and animals. Several important vertebrate viruses were identified in the pangolins, including parvovirus, pestivirus, and picobirnavirus. The picobirnavirus was clustered with human and grey teal picobirnaviruses. Viruses with cross-species transmission ability were also identified, including circovirus, rotavirus, and astrovirus. Our study revealed that pangolins are frequently exposed to arthropod-associated viruses in the wild and can carry many vertebrate viruses under natural conditions. This study provides important insights into the virome of pangolins, underscoring the importance of monitoring potential pathogens in healthy pangolins to prevent outbreaks of infectious diseases in domesticated animals and humans.
  • The data that support our findings were deposited in the NCBI database under BioProjectID PRJNA881017, as well as the Genome Sequence Archive (GSA) under accession no. PRJCA010128, and the Science Data Bank under DOI:10.57760/sciencedb.j00139.00041. The consensus sequences in this study were deposited in GenBank under accession numbers OP474153–OP474178 and in the NGDC Genome Warehouse (GWH) (https://ngdc.cncb.ac.cn/gwh/) under accession numbers GWHBJSI01000000–GWHBJTI01000000 (Supplementary Table S2).
    Supplementary data to this article can be found online.
    The authors declare that they have no competing interests.
    Y.G.T., M.S., T.C.Q., and Y.L.H. designed and supervised the research. T.C.Q. collected the samples. W.L.L., Y.J.L., Y.J.H., Q.H.T., Y.L., and Y.B. processed the samples. F.J.T. and J.L. performed data analysis, genome assembly, and phylogenetic analysis and contributed to data interpretation and wrote the paper. Y.G.T., M.S., T.C.Q., and Y.L.H. edited the paper. All authors read and approved the final version of the manuscript.
    #Authors contributed equally to this work
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