Volume 43 Issue 5
Sep.  2022
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Chi Zhang, Chuan-Lei Li, Ke-Xin Xu, Zhi-Huang Zheng, Guo-Zhe Cheng, Hui-Juan Wu, Jun Liu. The Hippo pathway and its correlation with acute kidney injury. Zoological Research, 2022, 43(5): 897-910. doi: 10.24272/j.issn.2095-8137.2022.110
Citation: Chi Zhang, Chuan-Lei Li, Ke-Xin Xu, Zhi-Huang Zheng, Guo-Zhe Cheng, Hui-Juan Wu, Jun Liu. The Hippo pathway and its correlation with acute kidney injury. Zoological Research, 2022, 43(5): 897-910. doi: 10.24272/j.issn.2095-8137.2022.110

The Hippo pathway and its correlation with acute kidney injury

doi: 10.24272/j.issn.2095-8137.2022.110
Funds:  This work was supported by the National Natural Science Foundation of China (82070718; 81770712) and Shanghai Science and Technology Innovation Natural Foundation (20ZR1444700)
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  • Acute kidney injury (AKI) is a significant clinical complication with a substantial impact on morbidity and mortality, for which therapeutic options remain limited. The Hippo signaling pathway is an evolutionarily conserved pathway implicated in cell proliferation, dedifferentiation, and apoptosis via phosphorylation and inactivation of its downstream effectors Yes-associated protein (YAP)/ transcriptional co-activator with PDZ-binding motif (TAZ). Recent studies have revealed that the Hippo pathway plays a pivotal role in the pathogenesis and repair of AKI. The Hippo pathway can mediate renal dysfunction through modulation of mitochondrial apoptosis under AKI conditions. Transient activation of YAP/TAZ in the acute phase of AKI may benefit renal recovery and regeneration, whereas persistent activation of YAP/TAZ in severe AKI may lead to maladaptive repair and transition to chronic kidney disease. This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI.
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