Engineered T cells and their therapeutic applications in autoimmune diseases

Lei Bao; Xiao-Chen Bo; Huai-Wen Cao; Chen Qian; Zeng Wang; Bin Li

doi:10.24272/j.issn.2095-8137.2021.363

Volume 43 Issue 2

Mar. 2022

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Lei Bao, Xiao-Chen Bo, Huai-Wen Cao, Chen Qian, Zeng Wang, Bin Li. Engineered T cells and their therapeutic applications in autoimmune diseases. Zoological Research, 2022, 43(2): 150-165. doi: 10.24272/j.issn.2095-8137.2021.363

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Lei Bao, Xiao-Chen Bo, Huai-Wen Cao, Chen Qian, Zeng Wang, Bin Li. Engineered T cells and their therapeutic applications in autoimmune diseases. Zoological Research, 2022, 43(2): 150-165. doi: 10.24272/j.issn.2095-8137.2021.363

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Engineered T cells and their therapeutic applications in autoimmune diseases

doi: 10.24272/j.issn.2095-8137.2021.363

Lei Bao¹,
Xiao-Chen Bo¹,
Huai-Wen Cao¹,
Chen Qian¹,
Zeng Wang^{1
,
,},
Bin Li^{1
,
,}

1.
Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Funds: This study was supported by the National Natural Science Foundation of China (81830051, 31961133011, 32130041); National Key R&D Program of China (2019YFA09006100); Shanghai Academic Research Leader (16XD1403800); Innovative Research Team of High-Level Local Universities in Shanghai; and Shanghai Collaborative Innovation Center of Cellular Homeostasis Regulation and Human Diseases

More Information

Corresponding author: E-mail: wz2573749689@126.com; binli@shsmu.edu.cn
Received Date: 2021-12-02
Accepted Date: 2022-01-06

Published Online: 2022-01-08

Publish Date: 2022-03-18

Abstract

Abstract

Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.
- Chimeric antigen receptor T cells,
- Cell immunotherapy,
- Autoimmune diseases

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References(147)

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