Volume 42 Issue 6
Nov.  2021
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Zhu Li, Yuan-Xiang Zhu, Li-Jun Gu, Ying Cheng. Understanding autism spectrum disorders with animal models: applications, insights, and perspectives. Zoological Research, 2021, 42(6): 800-824. doi: 10.24272/j.issn.2095-8137.2021.251
Citation: Zhu Li, Yuan-Xiang Zhu, Li-Jun Gu, Ying Cheng. Understanding autism spectrum disorders with animal models: applications, insights, and perspectives. Zoological Research, 2021, 42(6): 800-824. doi: 10.24272/j.issn.2095-8137.2021.251

Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

doi: 10.24272/j.issn.2095-8137.2021.251
#Authors contributed equally to this work
Funds:  This work was supported by the National Natural Science Foundation of China (82071540) and Yunnan University (CZ21623201)
More Information
  • Corresponding author: E-mail: ycheng@ynu.edu.cn
  • Received Date: 2021-09-26
  • Accepted Date: 2021-11-04
  • Published Online: 2021-11-04
  • Publish Date: 2021-11-18
  • Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its highly heterogeneous nature. To better understand the pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, and idiopathic animal models. In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models.
  • #Authors contributed equally to this work
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