Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice

Wen-Cong Gao; Xin Ma; Peng Wang; Xiao-Yan He; Yong-Tang Zheng; Feng-Liang Liu; Chang-Bo Zheng

doi:10.24272/j.issn.2095-8137.2021.206

Volume 42 Issue 5

Sep. 2021

Turn off MathJax

Article Contents

Article Navigation > Zoological Research > 2021 > 42(5): 633-636

Wen-Cong Gao, Xin Ma, Peng Wang, Xiao-Yan He, Yong-Tang Zheng, Feng-Liang Liu, Chang-Bo Zheng. Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice. Zoological Research, 2021, 42(5): 633-636. doi: 10.24272/j.issn.2095-8137.2021.206

Citation:

Wen-Cong Gao, Xin Ma, Peng Wang, Xiao-Yan He, Yong-Tang Zheng, Feng-Liang Liu, Chang-Bo Zheng. Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice. Zoological Research, 2021, 42(5): 633-636. doi: 10.24272/j.issn.2095-8137.2021.206

Citation:

Wen-Cong Gao, Xin Ma, Peng Wang, Xiao-Yan He, Yong-Tang Zheng, Feng-Liang Liu, Chang-Bo Zheng. Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice. Zoological Research, 2021, 42(5): 633-636. doi: 10.24272/j.issn.2095-8137.2021.206

PDF( 2569 KB)

Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice

doi: 10.24272/j.issn.2095-8137.2021.206

Wen-Cong Gao^{1, 2, #},
Xin Ma^{1, 2, #},
Peng Wang¹,
Xiao-Yan He²,
Yong-Tang Zheng^{2, 3},
Feng-Liang Liu^{2, 3
,
,},
Chang-Bo Zheng^{1
,
,}

1.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China
2.
Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
3.
Kunming National High-Level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China

#Authors contributed equally to this work

Funds: This work was supported by the National Key R & D Program of China (2020YFC0842000), National Natural Science Foundation of China (81960662), and Science and Technology Department of Yunnan Province (202001AS070034)

More Information

Corresponding author: E-mail: liufl@mail.kiz.ac.cn; zhengchangbo@kmmu.edu.cn
Received Date: 2021-06-21
Accepted Date: 2021-08-23

Published Online: 2021-08-23

Publish Date: 2021-09-18

Abstract

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent responsible for the global coronavirus disease 2019 (COVID-19) pandemic. Numerous studies have demonstrated that cardiovascular disease may affect COVID-19 progression. In the present study, we investigated the effect of hypertension on viral replication and COVID-19 progression using a hypertensive mouse model infected with SARS-CoV-2. Results revealed that SARS-CoV-2 replication was delayed in hypertensive mouse lungs. In contrast, SARS-CoV-2 replication in hypertensive mice treated with the antihypertensive drug captopril demonstrated similar virus replication as SARS-CoV-2-infected normotensive mice. Furthermore, antihypertensive treatment alleviated lung inflammation induced by SARS-CoV-2 replication (interleukin (IL)-1β up-regulation and increased immune cell infiltration). No differences in lung inflammation were observed between the SARS-CoV-2-infected normotensive mice and hypertensive mice. Our findings suggest that captopril treatment may alleviate COVID-19 progression but not affect viral replication.
- SARS-CoV-2,
- Hypertension,
- Captopril,
- Inflammation,
- Animal model

#Authors contributed equally to this work

FullText(HTML)

References(14)

References

[1]	Groel JT, Tadros SS, Dreslinski GR, Jenkins AC. 1983. Long-term antihypertensive therapy with captopril. Hypertension, 5(5 Pt 2): III-145−III-151.
[2]	Gu HJ, Chen Q, Yang G, He L, Fan H, Deng YQ, et al. 2020. Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. Science, 369(6511): 1603−1607. doi: 10.1126/science.abc4730
[3]	Hijriani N, Yusetyani L, Hasmono D. 2020. The effect of curcuma (Curcuma xanthorrizha roxb. ) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension. Journal of Basic and Clinical Physiology and Pharmacology, 30(6): 20190280.
[4]	Hsu CY, Huang LY, Saver JL, Wu YL, Lee JD, Chen PC, et al. 2019. Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. Hypertension Research, 42(11): 1794−1800. doi: 10.1038/s41440-019-0300-0
[5]	Liu FL, Wu KX, Sun JY, Duan ZL, Quan XZ, Kuang JQ, et al. 2021. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. National Science Review, 8(2): nwaa285.
[6]	Parra-Bracamonte GM, Lopez-Villalobos N, Parra-Bracamonte FE. 2020. Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico. Annals of Epidemiology, 52: 93−98.e2. doi: 10.1016/j.annepidem.2020.08.005
[7]	Pedrosa MA, Valenzuela R, Garrido-Gil P, Labandeira CM, Navarro G, Franco R, et al. 2021. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical Science, 135(3): 465−481. doi: 10.1042/CS20201511
[8]	Song TZ, Zheng HY, Han JB, Jin L, Yang X, Liu FL, et al. 2020. Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques. Zoological Research, 41(5): 503−516. doi: 10.24272/j.issn.2095-8137.2020.202
[9]	Tian RR, Yang CX, Zhang M, Feng XL, Luo RH, Duan ZL, et al. 2021. Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study. Zoological Research, 42(2): 161−169. doi: 10.24272/j.issn.2095-8137.2020.329
[10]	Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu JS, et al. 2020. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nature Immunology, 21(11): 1327−1335. doi: 10.1038/s41590-020-0778-2
[11]	Xu L, Yu DD, Ma YH, Yao YL, Luo RH, Feng XL, et al. 2020. COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2. Zoological Research, 41(5): 517−526. doi: 10.24272/j.issn.2095-8137.2020.053
[12]	Zhang MZ, Wang SW, Yang SL, Yang HC, Fan XF, Takahashi T, et al. 2012. Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS^-/- db/db mice. American Journal of Physiology-Renal Physiology, 302(4): F433−F438. doi: 10.1152/ajprenal.00292.2011
[13]	Zheng CB, Gao WC, Xie MX, Li ZC, Ma X, Song WC, et al. 2021. Ang II promotes cardiac autophagy and hypertrophy via orai1/STIM1. Frontiers in Pharmacology, 12: 622774. doi: 10.3389/fphar.2021.622774
[14]	Zhou Z, Ren LL, Zhang L, Zhong JX, Xiao Y, Jia ZL, et al. 2020. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host & Microbe, 27(6): 883−890.e2.