Parabiosis modeling: protocol, application and perspectives

Cui Yang; Zhi-Lan Liu; Jun Wang; Xian-Le Bu; Yan-Jiang Wang; Yang Xiang

doi:10.24272/j.issn.2095-8137.2020.368

Volume 42 Issue 3

May 2021

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Cui Yang, Zhi-Lan Liu, Jun Wang, Xian-Le Bu, Yan-Jiang Wang, Yang Xiang. Parabiosis modeling: protocol, application and perspectives. Zoological Research, 2021, 42(3): 253-261. doi: 10.24272/j.issn.2095-8137.2020.368

Citation:

Cui Yang, Zhi-Lan Liu, Jun Wang, Xian-Le Bu, Yan-Jiang Wang, Yang Xiang. Parabiosis modeling: protocol, application and perspectives. Zoological Research, 2021, 42(3): 253-261. doi: 10.24272/j.issn.2095-8137.2020.368

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Parabiosis modeling: protocol, application and perspectives

doi: 10.24272/j.issn.2095-8137.2020.368

Cui Yang^{1, 2},
Zhi-Lan Liu³,
Jun Wang⁴,
Xian-Le Bu⁴,
Yan-Jiang Wang^{4
,
,},
Yang Xiang^{5
,
,}

1.
Institute of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China
2.
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan 610072, China
3.
Department of Neurology, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
4.
Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400012, China
5.
Department of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China

Funds: This study was supported by the National Natural Science Foundation of China (81601112, 81801090), Top Project of Youth Incubation Program of Military Medical Science and Technology (19QNP065), Sichuan Department of Science and Technology Fund (2018SZ0141, 2019YSF0213), China’s Post-doctoral Science Fund (2017M623357), and Sichuan Medical Association Fund (Q17008)

More Information

Corresponding author: E-mail: yanjiang_wang@tmmu.edu.cn; xiangyangttt@126.com
Received Date: 2020-12-21
Accepted Date: 2021-03-04

Published Online: 2021-03-08

Publish Date: 2021-05-18

Abstract

Abstract

Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely accepted. However, researchers need to consider many details, from surgical operation to perioperative management, to reduce mortality and maintain the parabiosis union. Although parabiosis has certain inevitable limitations, it still has broad application prospects as an irreplaceable animal model in the medical research field.
- Parabiosis,
- Application,
- Protocols,
- Surgical technique,
- Perioperative management

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References(43)

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