Effects of aging on gene expression in blood of captive Tibetan macaques (<i>Macaca thibetana</i>) and comparisons with expression in humans

Chao-Chao Yan; Xin-Shang Zhang; Liang Zhou; Qiao Yang; Min Zhou; Lin-Wan Zhang; Jin-Chuan Xing; Zhi-Feng Yan; Megan Price; Jing Li; Bi-Song Yue; Zhen-Xin Fan

doi:10.24272/j.issn.2095-8137.2020.092

Volume 41 Issue 5

Sep. 2020

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Article Navigation > Zoological Research > 2020 > 41(5): 557-563

Chao-Chao Yan, Xin-Shang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Lin-Wan Zhang, Jin-Chuan Xing, Zhi-Feng Yan, Megan Price, Jing Li, Bi-Song Yue, Zhen-Xin Fan. Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans. Zoological Research, 2020, 41(5): 557-563. doi: 10.24272/j.issn.2095-8137.2020.092

Citation:

Chao-Chao Yan, Xin-Shang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Lin-Wan Zhang, Jin-Chuan Xing, Zhi-Feng Yan, Megan Price, Jing Li, Bi-Song Yue, Zhen-Xin Fan. Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans. Zoological Research, 2020, 41(5): 557-563. doi: 10.24272/j.issn.2095-8137.2020.092

Citation:

Chao-Chao Yan, Xin-Shang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Lin-Wan Zhang, Jin-Chuan Xing, Zhi-Feng Yan, Megan Price, Jing Li, Bi-Song Yue, Zhen-Xin Fan. Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans. Zoological Research, 2020, 41(5): 557-563. doi: 10.24272/j.issn.2095-8137.2020.092

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Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans

doi: 10.24272/j.issn.2095-8137.2020.092

1.
Key Laboratory of Bioresources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China
2.
Institute of Laboratory Animal Sciences, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610212, China
3.
Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA

#Authors contributed equally to this work

Funds: This work was supported by the National Natural Science Foundation of China 31501871 (Z.X.F.), Department of Science and Technology of Sichuan Province 2019JDZH0029 (X.Z.), Department of Science and Technology of Sichuan Province 2020JDZH0026 (X.Z.), and Academy of Medical Sciences & Sichuan Provincial People’s Hospital 2017QN06 (X.Z.)

More Information

Corresponding author: E-mail: zxfan@scu.edu.cn
Received Date: 2020-04-23
Accepted Date: 2020-06-18

Published Online: 2020-06-24

Publish Date: 2020-09-18

Abstract

Abstract

Changes in gene expression occur as animals, including primates, age. Macaques have long been used as a model species for primate evolution and biomedical studies. Here, to study gene expression in Tibetan macaques (Macaca thibetana, TMs) and its differences to humans, we applied RNA-Seq to obtain the blood transcriptomes of 24 TMs. In total, 2 523 age-associated differentially expressed genes (DEGs) were identified. Several pathways and processes that regulate aging, including the FoxO signaling pathway, autophagy, and platelet activation, were significantly enriched in the up-regulated DEGs. Two significantly age-related modules were identified by weighted gene co-expression network analysis (WGCNA). The TMs and humans shared 279 common DEGs, including 111 up-regulated and 141 down-regulated genes with advancing age in the same expression direction. However, 27 age-related DEGs presented the opposite expression direction in TMs as that in humans. For example, INPPL1, with inhibitory effects on the B cell receptor signaling pathway, was up-regulated in humans but down-regulated in TMs. In general, our study suggests that aging is a critical factor affecting gene expression in the captive TM population. The similarities and differences in gene expression patterns between TMs and humans could provide new insights into primate evolution and benefit TM model development.
- Gene expression,
- Aging,
- Macaque,
- Human,
- Transcriptome

#Authors contributed equally to this work

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References(41)

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