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Volume 41 Issue 3
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Article Navigation >  Zoological Research  > 2020  >  41(3): 220-230
Hong-Fa Yan, Qing-Zhang Tuo, Qiao-Zhi Yin, Peng Lei. The pathological role of ferroptosis in ischemia/reperfusion-related injury. Zoological Research, 2020, 41(3): 220-230. doi: 10.24272/j.issn.2095-8137.2020.042
Citation: Hong-Fa Yan, Qing-Zhang Tuo, Qiao-Zhi Yin, Peng Lei. The pathological role of ferroptosis in ischemia/reperfusion-related injury. Zoological Research, 2020, 41(3): 220-230. doi: 10.24272/j.issn.2095-8137.2020.042
shu

The pathological role of ferroptosis in ischemia/reperfusion-related injury

doi: 10.24272/j.issn.2095-8137.2020.042
  • 1.

    Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Center for Biotherapy, Chengdu, Sichuan 610041, China

  • 2.

    Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, China

Funds:  This study was supported by grants from the Ministry of Science and Technology of China (2018YFC1312300), National Natural Science Foundation of China (81722016, 81801182), Sichuan Science and Technology Program (2018JPT0037, 2018SZ0190), and China Postdoctoral Science Foundation (2017M623041)
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    Abstract

  • Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.

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