Pseudogenization of the <em>Humanin</em> gene is common in the mitochondrial DNA of many vertebrates

Ian S. Logan

doi:10.24272/j.issn.2095-8137.2017.049

Volume 38 Issue 4

Jul. 2017

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Ian S. Logan. Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates. Zoological Research, 2017, 38(4): 198-202. doi: 10.24272/j.issn.2095-8137.2017.049

Citation:

Ian S. Logan. Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates. Zoological Research, 2017, 38(4): 198-202. doi: 10.24272/j.issn.2095-8137.2017.049

Ian S. Logan. Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates. Zoological Research, 2017, 38(4): 198-202. doi: 10.24272/j.issn.2095-8137.2017.049

Citation:

Ian S. Logan. Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates. Zoological Research, 2017, 38(4): 198-202. doi: 10.24272/j.issn.2095-8137.2017.049

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Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates

doi: 10.24272/j.issn.2095-8137.2017.049

Ian S. Logan

22 Parkside Drive, Exmouth, Devon, UK

Received Date: 2017-05-20
Rev Recd Date: 2017-07-05
Publish Date: 2017-07-18

Abstract

Abstract

In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.
- mtDNA,
- Humanin,
- Pseudogenization,
- NUMT

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References(28)

References

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