Volume 37 Issue 4
Jul.  2016
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Xin LUO, Min LI, Bing SU. Application of the genome editing tool CRISPR/Cas9 in non-human primates. Zoological Research, 2016, 37(4): 214-219. doi: 10.13918/j.issn.2095-8137.2016.4.214
Citation: Xin LUO, Min LI, Bing SU. Application of the genome editing tool CRISPR/Cas9 in non-human primates. Zoological Research, 2016, 37(4): 214-219. doi: 10.13918/j.issn.2095-8137.2016.4.214

Application of the genome editing tool CRISPR/Cas9 in non-human primates

doi: 10.13918/j.issn.2095-8137.2016.4.214
Funds:  the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13010000) and the National Natural Science Foundation of China (31130051)
More Information
  • Corresponding author: Bing SU
  • Received Date: 2015-12-10
  • Rev Recd Date: 2016-05-20
  • Publish Date: 2016-07-18
  • In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.
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