Genetic Polymorphism of Epithelial Mucin,MUC1,in Milk of Goats

The epithelial mucin,MUC1,was assayed using the SDS-PAGE method in individual milk samples from five populations,Boer goat,Chengdu Ma goat,Angora goat×Tibetan goat F1,Jianchang black goat and Angora goat×Jianchang black goat F1.Polymorphism is found in these goats milk MUC1 with one or two bands showing the variable mobility and being stained the equal intensity.The bands present four polymorphic forms,I.e.A,B,C and D with molecular weights 264,241,231 and 220 kDa respectively,which are higher than those in Yak and Holstein cattle previously reported.There are differences in MUC1 genotype among the goat breeds:Boer goat exhibits ten genotypes and its gene heterozygosity is 0.7272,Jianchang black goat exhibits three genotypes and its gene heterozygosity is 0.4950,however Chengdu Ma goat only exhibits one CC genotype.Genotype distribution of milk MUC1 in Boer goat,Chengdu Ma goat and Jianchang black goat is in accordance with Hardy-Weinberg law.