Effects of Clenbuterol on IGF-Ⅰ,GH and Insulin Level of Hepatic Blood in Sheep

Four sheep installed chronic catheters in the portal vein,hepatic vein and mesenteric vein were used to study the effects of clenbuterol on metabolic hormones.The results are:1)The GH level of portal vein is markedly increased during clenbuterol treatment period (0.8 mg/kg BW,twice daily for five days);2)The GH level of hepatic vein with clenbuterol-treated is similar to that of control;3)The IGF-Ⅰ concentration of hepatic vein is markedly elevated and IGF-Ⅰ of portal vein is maintained a higher level in clenbuterol treatment period.4)The insulin concentration of hepatic blood is decreased with clenbuterol-treated.These showed that the changes of those hormone levels in clenbuterol treatment played an important role in regulation of growth and metabolism in sheep.