Temporal and Spatial Expression Patterns of Sox1 Gene in Xenopus laevis Embryo
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Abstract
We describe the temporal and spatial expression pattern of Sox1 gene during Xenopus laevis early development and compare the expression patterns of Sox1-3 in the developing eye and brain. Alignment of Sox1-3 amino acid sequences shows a high conservation within the HMG-box DNA binding domains. RT-PCR analysis indicates that Sox1 is expressed throughout development from the unfertilized egg to at least the tadpole stage, although at different expression levels. The transcripts of XSox1 are detected in the animal pole at cleavage and blastrula stages and mainly in the central nervous system (CNS) and the developing eye at neurula stages. The study of the developmental expression of XSox1 will aid in the elucidation of the function of SoxB1 subgroup genes in vertebrate neurogenesis.
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