Comparative Studies of The Inhibition of Four Vipera russelli Venoms on Platelet Aggregation

The inhibition of RVV from different source on platelet aggregation induced by ADP,Collagen or Ristocetin were studied.RVV-B,RVV-S and RVV-Styp could inhibited aggregation induced by above reagents.RVV-T could inhibited aggregation induced by ADP and Collagen,but not by Ristocetin.Platelets preincubated with RVV were resuspended in PPP after washed.It was observed that platelets preincubated with RVV-Styp could entirely restored to respond to Ristocetin,but only partially with RVV-B and RVV-S.These results shown that two distinct platelet inhibitory activities in RVV exist,the mechanism of the inhibition could involved platelet,plasma and other factors.