The Action of Fibrinolytic Principle Obtained From the Venom of Agkistrodon Halys (Pallas) on Blood Coagulation System

The fibrinolytic principle was obtained by twice DEAE-Sephadex A-50 column chromatography and Sephadex G-100 gel filtration from the venom of Agkistrodon halys Pallas.The experiment both in vitro and in vivo suggests that the fibrinolytic principle has actions on fibrin and fibrinogen and is able to hydrolyze factor Ⅷ and factor Ⅴ.The properties of the fibrinolytic principle of Agkistrodon halys Pallas venom are similar to those of plasmin,therefore,it is a plasmin-like substance.