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Yanqi Zhang, Peng Zhang, Junjun Wang, Jing Zhang, Tianyang Tong, Xiujuan Zhou, Yajie Zhou, Mengke Wei, Chuanlin Feng, Jinqian Li, Xin Zhang, Can Xie, Tiantian Cai. The mitochondrial targeting sequence of magnetoreceptor MagR: more than just targeting. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.385
Citation: Yanqi Zhang, Peng Zhang, Junjun Wang, Jing Zhang, Tianyang Tong, Xiujuan Zhou, Yajie Zhou, Mengke Wei, Chuanlin Feng, Jinqian Li, Xin Zhang, Can Xie, Tiantian Cai. The mitochondrial targeting sequence of magnetoreceptor MagR: more than just targeting. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.385

The mitochondrial targeting sequence of magnetoreceptor MagR: more than just targeting

doi: 10.24272/j.issn.2095-8137.2023.385
Funds:  This study was supported by the National Natural Science Foundation of China (31640001 and T2350005 to C.X., U21A20148 to X.Z. and C.X.), Ministry of Science and Technology of China (2021ZD0140300 to C.X.); The Natural Science Foundation of Hainan Province (No.822RC703 for J.L.); The Foundation of Hainan Educational Committee (No.Hnky2022-27 for J.L.) and Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences (Y96XC11131, E26CCG27, and E26CCD15 to C.X., E36CWGBR24B and E36CZG14132 to T.C.)
  • Received Date: 2023-12-13
  • Accepted Date: 2024-01-24
  • Rev Recd Date: 2024-01-22
  • Published Online: 2024-01-26
  • Iron-sulfur (Fe-S) clusters are essential cofactors of proteins involved in various biological systems, such as electron transport, biosynthetic reactions, DNA repair and gene expression regulation and so on. Iron-sulfur cluster assembly protein IscA1 or MagR was found in mitochondria of most eukaryotes. MagR is a highly conserved A-type iron and iron-sulfur cluster binding protein, with two types of iron-sulfur clusters, [2Fe-2S] and [3Fe-4S], each conferring distinct magnetic properties. It forms a rod-like polymer structure in complex with photoreceptive cryptochrome (Cry) and serve as a putative magnetoreceptor to retrieve geomagnetic information in animal navigation. The N-terminal sequences of MagR are divergent in different species, however, the specific function is unknown. Here, in this study we find that the N-terminal sequences of pigeon MagR which was assumed as the mitochondrial targeting signal (MTS) were not cleaved after entry into the mitochondria but instead affected the binding efficiency of iron-sulfur clusters and irons. Moreover, the MagR/Cry complex formation was also dependent on N-terminal region of MagR. Thus, the N-terminal sequences play more important functional roles than mitochondrial targeting in pigeon MagR. These results further extended our understanding about the function of MagR and may provide new insights into the origin of magnetoreception from evolutional view.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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