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Weifeng Shi, Yongtang Zheng, Hong Zhou, Ren-Rong Tian, Xiurong Wang, Jingxuan Yang, Yunxiao Wang, Mingliang Zhao, Xudong Zhang, Yuhua Ma, Long-Bao Lv, Edward C. Holmes. Identification of Novel Mammalian Viruses in Tree Shrews (Tupaia belangeri chinensis). Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.306
Citation: Weifeng Shi, Yongtang Zheng, Hong Zhou, Ren-Rong Tian, Xiurong Wang, Jingxuan Yang, Yunxiao Wang, Mingliang Zhao, Xudong Zhang, Yuhua Ma, Long-Bao Lv, Edward C. Holmes. Identification of Novel Mammalian Viruses in Tree Shrews (Tupaia belangeri chinensis). Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.306

Identification of Novel Mammalian Viruses in Tree Shrews (Tupaia belangeri chinensis)

doi: 10.24272/j.issn.2095-8137.2023.306
  • Received Date: 2023-09-24
  • Accepted Date: 2023-12-22
  • Rev Recd Date: 2023-12-14
  • Published Online: 2023-12-26
  • The Chinese tree shrew (Tupaia belangeri chinensis) is from a mammalian order (Scandentia) related to primates. Its nervous, immune, and metabolic systems are similar to those of primates, including humans, making it widely used as a promising experimental model in biomedical research, such as cancer, infectious, metabolic, and mental diseases models. Herein, we used meta-transcriptomic sequencing to analyze plasma, oral and anal swab samples from 105 apparently healthy tree shrew individuals to identify potential zoonotic viruses. Eight mammalian viruses with complete genomes were identified, belonging to six viral families: Flaviviridae, Hepeviridae, Parvovirinae, Picornaviridae, Sedoreoviridae, and Spinareoviridae. We reported, for the first time, a rotavirus in tree shrews. Of particular note were three viruses – hepacivirus1, parvovirus, and picornavirus – that exhibited low genetic similarity (<70%) with previously reported viruses at the scale of whole genome and so were novel. Three other viruses – hepacivirus 2, hepatovirus A and hepevirus – exhibited high similarity (>94%) to known viruses. Phylogenetic analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study might be novel reassortants. These findings provided insights into the wide virus spectrum in captive Chinese tree shrews. The potential for the cross-species transmission of these viruses from tree shrews to other animals clearly warrants further investigation.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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