Turn off MathJax
Article Contents
Gaolin Qiu, Lijun Peng, Peng Wang, Zhilai Yang, Jiqian Zhang, Hu Liu, Xiaona Zhu, Jin Rao, Xuesheng Liu. In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics in propofol or sevoflurane anesthesia. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.302
Citation: Gaolin Qiu, Lijun Peng, Peng Wang, Zhilai Yang, Jiqian Zhang, Hu Liu, Xiaona Zhu, Jin Rao, Xuesheng Liu. In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics in propofol or sevoflurane anesthesia. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.302

In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics in propofol or sevoflurane anesthesia

doi: 10.24272/j.issn.2095-8137.2023.302
Funds:  This work was supported by National Natural Science Foundation of China (No.81870841 and No. 82171192) to XL; National Natural Science Foundation of China(No. 82101349) to GQ.
  • Received Date: 2023-09-19
  • Accepted Date: 2023-12-08
  • Rev Recd Date: 2023-12-07
  • Published Online: 2023-12-26
  • General anesthesia is widely applied in clinical practice. However, the precise mechanism of loss of consciousness induced by general anesthetics remains unknown. Here, we measured the dynamics of five neurotransmitters, including γ-aminobutyric acid, glutamate, norepinephrine, acetylcholine, and dopamine in the medial prefrontal cortex and the primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from the perspective of neurotransmitters. We discovered that the concentrations of γ-aminobutyric acid, glutamate, norepinephrine, and acetylcholine in the cortex increased during propofol-induced loss of consciousness. The dopamine concentration did not change following the hypnotic dose of propofol; however, the concentration increased significantly following surgical doses of propofol anesthesia. Notably, the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of consciousness. Moreover, in the non-anesthesia groups, the neurotransmitter dynamic networks were not synchronized; however, in the anesthetic groups, the neurotransmitter dynamic networks were highly synchronized. These data revealed that neurotransmitter dynamics network synchronization may cause anesthetic-induced loss of consciousness.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (95) PDF downloads(5) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return