Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Stem Cell and Reproductive Biology
Chinese PLA General Hospital Department of Otolaryngology‑Head and Neck Surgery, Institute of Otolaryngology
This research is supported by the National Key Research and Development Program of China (2021YFA0805902, 2022YFF0710703), the National Natural Science Foundation of China (32201257), the Science and Technology Innovation Project of Xiongan New Area (2022XAGG0121), and the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology (2019QNRC001).
Hereditary hearing loss (HHL) is a genetic disorder that impairs auditory function, and it can seriously affect the quality of human life and lead to major economic losses for society. To investigate the underlying causes of HHL and evaluate therapeutic outcomes, appropriate animal models are necessary. Recently, pigs have been widely used as valuable large model animals in biomedical research. In this review, we highlight the advantages of pig models in terms of ear anatomy, inner ear morphology and electrophysiological characteristics, as well as the recent progress in establishing distinct genetically modified porcine models of hearing loss. Additionally, we present the prospects, obstacles and recommendations in using pig models for HHL research. This review should provide insights and perspectives for the future research of porcine models for HHL.