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Xiao Wang, Tianxia Liu, Ying Zhang, LiangWei Xu, ShuoLong Yuan, WeiWei Guo, ShiMing Yang, Jianguo Zhao. Genetically modified pigs: Emerging animal models for hereditary hearing loss. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.231
Citation: Xiao Wang, Tianxia Liu, Ying Zhang, LiangWei Xu, ShuoLong Yuan, WeiWei Guo, ShiMing Yang, Jianguo Zhao. Genetically modified pigs: Emerging animal models for hereditary hearing loss. Zoological Research. doi: 10.24272/j.issn.2095-8137.2023.231

Genetically modified pigs: Emerging animal models for hereditary hearing loss

doi: 10.24272/j.issn.2095-8137.2023.231
Funds:  This research is supported by the National Key Research and Development Program of China (2021YFA0805902, 2022YFF0710703), the National Natural Science Foundation of China (32201257), the Science and Technology Innovation Project of Xiongan New Area (2022XAGG0121), and the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology (2019QNRC001).
  • Received Date: 2023-07-22
  • Accepted Date: 2023-11-02
  • Rev Recd Date: 2023-10-23
  • Published Online: 2023-12-06
  • Hereditary hearing loss (HHL) is a genetic disorder that impairs auditory function, and it can seriously affect the quality of human life and lead to major economic losses for society. To investigate the underlying causes of HHL and evaluate therapeutic outcomes, appropriate animal models are necessary. Recently, pigs have been widely used as valuable large model animals in biomedical research. In this review, we highlight the advantages of pig models in terms of ear anatomy, inner ear morphology and electrophysiological characteristics, as well as the recent progress in establishing distinct genetically modified porcine models of hearing loss. Additionally, we present the prospects, obstacles and recommendations in using pig models for HHL research. This review should provide insights and perspectives for the future research of porcine models for HHL.
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