Abstract: In the present study,water samples of 7 localities in round water areas of Fuxian Lake were used for comparison with different areas water quality and mutagenicity.The qualitative and quantitative determinations of inorganic pollutants in water samples were made by ICP-AES spectrometry.We used the micronucleus test of tadpole (Bufo bufo andrewsi) erythrocytes to investigate the potential mutagenicity of water samples from Fuxian Lake.The results obtained showed that,among 7 localities in round water areas of Fuxian Lake,2 localities of Luchong and Mingxing had mutagenic active substances as manifested by an increase in the frequency of the micronucleated erythrocytes.