Abstract: This paper reviewed the recent researches on the stanniocalcin (STC) produced by the corpuscles of Stannius in teleost.STCs are homodimeric glycoprotein hormones with apparent molecular weight ranging from 46 kDa(chum salmon)to 56 kDa (rainbow trout) in native form and 23-28 kDa in the reduced condition.The amino acid sequence analyses of STCs and cDNAs have revealed that reduced STCs (monomer) consist of 179 (chum salmon),223 (coho salmon) and 231 (Australian eel) amino acid residues,respectively.Other studies show that secretion of STC is regulated by calcium concentrations and that the cholinergic nerves are involved in the release of STC.