Abstract: The percentage of the rosette formation cell,such as Et,Ea,ZYC and ME of peripheral blood of lymphoid of rhesus monkey with and without prefronal cortex lesions were examinated at 7th day and 30th day after operation with immune-rosette technique.The results were as follows:1.The percentage of Ea and ME decreaced statistically at 7th day to 30th day after prefronal cortex biolateral lesions.2.The percentage of Et and ZYC decreaced statistically after biolateral lesions 7th day and has recovered at 30th day after operation.This suggested that prefronal cortex might modutate the immunity of organism.The mechanism of modulated will be studied further.