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宋婷, 周军. 2020: 原生纤毛在角膜发育和疾病中的作用. 动物学研究, 41(5): 495-502. DOI: 10.24272/j.issn.2095-8137.2020.109
引用本文: 宋婷, 周军. 2020: 原生纤毛在角膜发育和疾病中的作用. 动物学研究, 41(5): 495-502. DOI: 10.24272/j.issn.2095-8137.2020.109
Ting Song, Jun Zhou. 2020: Primary cilia in corneal development and disease. Zoological Research, 41(5): 495-502. DOI: 10.24272/j.issn.2095-8137.2020.109
Citation: Ting Song, Jun Zhou. 2020: Primary cilia in corneal development and disease. Zoological Research, 41(5): 495-502. DOI: 10.24272/j.issn.2095-8137.2020.109

原生纤毛在角膜发育和疾病中的作用

Primary cilia in corneal development and disease

  • 摘要: 角膜是位于眼球前部的透明的无血管组织,是防止外部损伤的重要屏障。角膜的上皮细胞和内皮细胞都具有原生纤毛,它们可以感知外部环境的变化并调节细胞内信号通路。越来越多的证据表明,原生纤毛以多种方式调节角膜的发育,包括参与角膜上皮分层和维持角膜内皮细胞形态。此外,原生纤毛也参与了角膜疾病的发病过程。在这篇综述中,我们讨论了原生纤毛与角膜发育近年来的报道,明确了原生纤毛在角膜发育中的关键作用。同时我们还讨论了纤毛功能异常和角膜疾病之间的联系,为靶向原生纤毛来治疗角膜疾病提供依据。

     

    Abstract: As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases.

     

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