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陈琦, 马朝霞, 夏丽滨, 叶珍妮, 刘宝玲, 马铁昆, 保鹏飞, 吴兴飞, 余从涛, 马代萍, 罕园园, 王文广, 匡德宣, 代解杰, 张荣平, 胡敏, 石宏, 王文林, 李燕皎. 2020: 一种激素相关性骨坏死树鼩模型. 动物学研究, 41(5): 564-568. DOI: 10.24272/j.issn.2095-8137.2020.061
引用本文: 陈琦, 马朝霞, 夏丽滨, 叶珍妮, 刘宝玲, 马铁昆, 保鹏飞, 吴兴飞, 余从涛, 马代萍, 罕园园, 王文广, 匡德宣, 代解杰, 张荣平, 胡敏, 石宏, 王文林, 李燕皎. 2020: 一种激素相关性骨坏死树鼩模型. 动物学研究, 41(5): 564-568. DOI: 10.24272/j.issn.2095-8137.2020.061
Qi Chen, Zhao-Xia Ma, Li-Bin Xia, Zhen-Ni Ye, Bao-Ling Liu, Tie-Kun Ma, Peng-Fei Bao, Xing-Fei Wu, Cong-Tao Yu, Dai-Ping Ma, Yuan-Yuan Han, Wen-Guang Wang, De-Xuan Kuang, Jie-Jie Dai, Rong-Ping Zhang, Min Hu, Hong Shi, Wen-Lin Wang, Yan-Jiao Li. 2020: A tree shrew model for steroid-associated osteonecrosis. Zoological Research, 41(5): 564-568. DOI: 10.24272/j.issn.2095-8137.2020.061
Citation: Qi Chen, Zhao-Xia Ma, Li-Bin Xia, Zhen-Ni Ye, Bao-Ling Liu, Tie-Kun Ma, Peng-Fei Bao, Xing-Fei Wu, Cong-Tao Yu, Dai-Ping Ma, Yuan-Yuan Han, Wen-Guang Wang, De-Xuan Kuang, Jie-Jie Dai, Rong-Ping Zhang, Min Hu, Hong Shi, Wen-Lin Wang, Yan-Jiao Li. 2020: A tree shrew model for steroid-associated osteonecrosis. Zoological Research, 41(5): 564-568. DOI: 10.24272/j.issn.2095-8137.2020.061

一种激素相关性骨坏死树鼩模型

  • 摘要: 骨坏死是骨科常见的人类疾病。治疗困难,半数患者可能需要人工关节置换,造成较大的经济负担,导致生活质量下降。激素是造成骨坏死的主要原因之一,高剂量的皮质类固醇被认为是造成骨坏死最危险的因素。由于该病治疗的复杂性,我们需要更好的动物模型,可以广泛用于药物开发和测试等。树鼩与灵长类动物的关系比啮齿类动物和灵长类动物的关系更密切。我们成功建立了一个树鼩模型来建立和评估类固醇相关性骨坏死(SAON)。联合使用低剂量脂多糖(LPS)和高剂量甲基强的松龙(MPS),12周后可建立骨坏死树鼩模型。血清生化和组织病理学分析表明,该树鼩模型是理想的。因此,这项工作为类固醇相关性骨坏死的研究和治疗方法的优化提供了一个有用的动物模型。

     

    Abstract: Osteonecrosis is a common human disease in orthopedics. It is difficult to treat, and half of patients may need artificial joint replacement, resulting in a considerable economic burden and a reduction in quality of life. Hormones are one of the major causes of osteonecrosis and high doses of corticosteroids are considered the most dangerous factor. Because of the complexity of treatment, we still need a better animal model that can be widely used in drug development and testing. Tree shrews are more closely related to primates than rodents. As such, we constructed a successful tree shrew model to establish and evaluate steroid-associated osteonecrosis (SAON). We found that low-dose lipopolysaccharide (LPS) combined with high-dose methylprednisolone (MPS) over 12 weeks could be used to establish a tree shrew model with femoral head necrosis. Serum biochemical and histological analyses showed that an ideal model was obtained. Thus, this work provides a useful animal model for the study of SAON and for the optimization of treatment methods.

     

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