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Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)

Ming-Xu Zhang Tian-Zhang Song Hong-Yi Zheng Xue-Hui Wang Ying Lu Han-Dan Zhang Ting Li Wei Pang Yong-Tang Zheng

Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Xue-Hui Wang, Ying Lu, Han-Dan Zhang, Ting Li, Wei Pang, Yong-Tang Zheng. Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). Zoological Research, 2019, 40(6): 522-531. doi: 10.24272/j.issn.2095-8137.2019.047
Citation: Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Xue-Hui Wang, Ying Lu, Han-Dan Zhang, Ting Li, Wei Pang, Yong-Tang Zheng. Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). Zoological Research, 2019, 40(6): 522-531. doi: 10.24272/j.issn.2095-8137.2019.047

良好的肠道完整性及低微生物易位有助于SIVmac239感染的北平顶猴维持低

doi: 10.24272/j.issn.2095-8137.2019.047

Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)

Funds: This work was partly supported by grants from the National Natural Science Foundation of China(U1802284);13th Five-Year Key Scientific and Technological Program of China(2017ZX10304402-002-004);Knowledge Innovation Program of the Chinese Academy of Sciences(ZDRW-ZS-2016-4)
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    Corresponding author: Yong-Tang Zheng
  • 摘要: 微生物易位导致HIV及SIV感染后系统性免疫活化是艾滋病发病的重要原因之一。我们发现在SIVmac239感染期间,北平顶猴CD8+ T细胞活化水平显著低于中国恒河猴。另外,其血浆脂多糖结合蛋白及可溶性CD14水平同样低于中国恒河猴。相较于中国恒河猴,北平顶猴的Chiu评分明显更低,这意味着其能维持更好的肠道完整性。无论在SIV感染或未感染的北平顶猴回肠和结肠上皮层均未发现明显的损伤,这一点不同于中国恒河猴。而且,在SIV感染或未感染的北平顶猴回肠和结肠部位均未检测到明显的微生物易位。以上研究结果表明,北平顶猴在SIV感染期间维持良好的肠道完整性及低水平的微生物易位可能是其CD8+ T细胞活化水平更低的重要原因。
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出版历程
  • 收稿日期:  2018-12-13
  • 录用日期:  2019-03-07
  • 刊出日期:  2019-10-14

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