Abstract: Mammalian gender preselection is to achieve desired offspring sex ratio by means of sperm sexing or embryo sexing.Due to its promising application in the field of human health and stock breeding,its a longing desire for the human being.In this article,we reviewed the history of the development of gender preselection methods and the latest advances in this field.For each method,its commented on the theoretical foundation,the advantage and disadvantage,their potential in the practical usage and the future development.