Abstract: We have observed outstanding inhibition of sarcoma 180 to ehrlich asciters in vitro and vivo of the nice. After inoculation Bungarus fasciatus,Najanaja venoms which is purified from B.fasciatus,Naja naja and Ophiophagus into mice with S180,EAC,survival rate increased than normal (P<0.001) and it delay the survival time and decrease the inoculating mice to transplant to other mices.But the effects of P.O.or injection of B.multicinctus are not evident.only act at the level of cell membrane,but also at the level of nuclear membrane leading to the change in various parts of the cells and the cytotoxin effects in vivo and in vitro are discussed in paper as well.