Abstract: The present investigation was compared on nature of pharmacodynamics and toxicology from Scolopendra mojiangica Zhang et Chi and Scolopendra subspinipes mutilans L.Koch.The experimental contents include anticonvulsive tests,effects on the growth of fungi and bacteria in vitro,acute toxicity tests,effects on animal weight and hemoglobin,chromosomal aberration tests and so on.The results showed that all of these properties of two centipedes were basically similar and this theoretically proved the possibility that Mojiang centipede can replace the Shaoji centipede on medicine.The acute toxicities and genetic toxicities of two centipedes were low,so that these two centipedes can be used larger dosage in clinical treatment.