Volume 25 Issue 4
Jul.  2004
Turn off MathJax
Article Contents
ZHANG Gao-hong, CHEN Ya-li, TANG Hong, ZHENG Yong-tang. Humanized SCID Mouse:A Small Animal Model for HIV Research. Zoological Research, 2004, 25(4): 356-362.
Citation: ZHANG Gao-hong, CHEN Ya-li, TANG Hong, ZHENG Yong-tang. Humanized SCID Mouse:A Small Animal Model for HIV Research. Zoological Research, 2004, 25(4): 356-362.

Humanized SCID Mouse:A Small Animal Model for HIV Research

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2004-08-22
  • A limitation in advancing the study of HIV-1 is the lack of a suitable small animal model system that allows for HIV-1 infection to be monitored.A mouse model of AIDS would be very useful because of it practicality and the ready availability of knowledge,reagents and immunogenetics.SCID-hu (Thy/Liv) mouse model,in which human fetal thymus and liver tissue are co-implanted into severe combined immunodeficient mice and resulting in a functional human hematopoietic organ (Thy/Liv),recapitulates the effects of HIV-1 infection in the human thymus.SCID-hu (Thy/Liv) mice are attractive and well-established small animal models for the study of HIV-1 infection in vivo.The humanized SCID mouse model would be served as valuable tools for in vivo studying pathogenesis of HIV,analysis of candidate anti-HIV drugs and vaccines prior to their clinical evaluation in human.
  • loading
  • Relative Articles

    [1] Tian-Zhang Song, Ming-Xu Zhang, Yu-Jie Xia, Yu Xiao, Wei Pang, Yong-Tang Zheng. Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239. Zoological Research, 2018, 39(1): 42-51.  doi: 10.24272/j.issn.2095-8137.2018.015
    [2] Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14.  doi: 10.24272/j.issn.2095-8137.2017.052
    [3] Wei-Na Guo, Bin Zhu, Ling Ai, Dong-Liang Yang, Bao-Ju Wang.  Animal models for the study of hepatitis B virus infection. Zoological Research, 2018, 39(1): 25-31.  doi: 10.24272/j.issn.2095-8137.2018.013
    [4] Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu. Development and characterization of a guinea pig model for Marburg virus. Zoological Research, 2018, 39(1): 32-41.  doi: 10.24272/j.issn.2095-8137.2017.054
    [5] Yong-Gang Yao. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?. Zoological Research, 2017, 38(3): 118-126.  doi: 10.24272/j.issn.2095-8137.2017.032
    [6] Ji Xiao, Rong Liu, Ce-Shi Chen. Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model. Zoological Research, 2017, 38(3): 127-137.  doi: 10.24272/j.issn.2095-8137.2017.033
    [7] Ming GUO, Wen-Zhe HO. Animal models to study Mycobacterium tuberculosis and HIV co-infection. Zoological Research, 2014, 35(3): 163-169.  doi: 10.11813/j.issn.0254-5853.2014.3.163
    [8] Ai-Hua LEI, Wei PANG, Gao-Hong ZHANG, Yong-Tang ZHENG. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 2013, 34(2): 77-88.  doi: 10.3724/SP.J.1141.2013.02077
    [9] WANG Wen-Guang, HUANG Xiao-Yan, XU Juan, SUN Xiao-Mei, DAI Jie-Jie, LI Qi-Han. Experimental studies on infant Tupaia belangeri chineses with EV71 infection. Zoological Research, 2012, 33(1): 7-13.  doi: 10.3724/SP.J.1141.2012.01007
    [10] GUO Li-Yun, WEI Jing-Kuan, YANG Shang-Chuan, WANG Zheng-Bo. Glaucoma model for stem cell transplantation research in New Zealand white rabbits. Zoological Research, 2012, (2): 225-230.  doi: 10.3724/SP.J.1141.2012.02225
    [11] ZHU Hui-Fang, ZHANG Yuan-Xu, ZHAO Xu-Dong. Animal models of human glioma: the progress of application and investigation. Zoological Research, 2012, 33(3): 337-342.  doi: 10.3724/SP.J.1141.2012.03337
    [12] CAO Guang, LIU Feng-Liang, ZHANG Gao-Hong, ZHENG Yong-Tang. The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication. Zoological Research, 2012, 33(1): 99-107.  doi: 10.3724/SP.J.1141.2012.01099
    [13] LI Yao, DAI Jie-Jie, SUN Xiao-Mei, XIA Xue-Shan. Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model. Zoological Research, 2011, 32(1): 97-103.  doi: 10.3724/SP.J.1141.2011.01097
    [14] CAO Guang, NIE Wen-Hui, LIU Feng-Liang, KUANG Yi-Qun, WANG Jin-Huan, SU Wei-Ting, ZH Y. Identification of the TRIM5/TRIMCyp heterozygous genotype in Macaca assamensis. Zoological Research, 2011, 32(1): 40-49.  doi: 10.3724/SP.J.1141.2011.01040
    [15] XIA Hou-JUN, ZHANG Gao-Hong, ZHENG Yong-Tang. Roles of Dendritic Cell in Disease Progression of AIDS Primate Models. Zoological Research, 2010, 31(1): 57-65.  doi: 10.3724/SP.J.1141.2010.01057
    [16] ZHU Lin, ZHANG Gao-Hong, ZHENG Yong-Tang. Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides. Zoological Research, 2010, 31(1): 66-76.  doi: 10.3724/SP.J.1141.2010.01066
    [17] HANG Gao-hong, LI Ming-hua, ZHENG Yong-tang. Application of AIDS Macaque Animal Model in HIV Vaccine Research. Zoological Research, 2007, 28(5): 556-562.
    [18] WANG Jian-hua, WANG Yuan-yuan, OUYANG Dong-yun, ZHENG Yong-tang. Apoptosis in Human Immunodeficiency Virus Infection. Zoological Research, 2002, 23(6): 514-520.
    [19] GUO Ren, CHEN Shu-fan, LUO Qi-sheng, WANG Qing-ling, YI Hong-kun, ZHAN Qiong-fen. Transgenic Mice as A Model For Neurovirulence Test of Live Poliomyelitis Vaccines. Zoological Research, 1999, 20(4): 241-246.
    [20] HUANG Hai, BEN Kun-long, ZHENG Yong-tang. Current Status in Research on Animal Models For human Aquired Immunodeficiency Syndrome. Zoological Research, 1997, 18(1): 121-128.
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2350) PDF downloads(4474) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint