Volume 29 Issue 2
Mar.  2008
Turn off MathJax
Article Contents
ZHANG Zheng-liang, WEN Bo, TANG Chuan-hong, HUA Tian-miao. Aged Changes of Glu/GABA Expression in the Cerebellar Cortex of Cats. Zoological Research, 2008, 29(2): 152-158.
Citation: ZHANG Zheng-liang, WEN Bo, TANG Chuan-hong, HUA Tian-miao. Aged Changes of Glu/GABA Expression in the Cerebellar Cortex of Cats. Zoological Research, 2008, 29(2): 152-158.

Aged Changes of Glu/GABA Expression in the Cerebellar Cortex of Cats

More Information
  • Corresponding author: HUA Tian-miao
  • Received Date: 2007-12-19
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2008-04-22
  • The physiological function of cerebellum declines during ageing, but its neural mechanism is not still clear. Therefore, we applied an immunohistochemical method to exhibit the Glu and GABA immunoreactive (Glu-IR and GABA-IR) cells, to investigate aged changes of Glu/GABA expression in the cerebellar cortex of young adult and old cats, and to discuss the possible impact of these changes. Under the Olympus BX-51 light microscope, the density of the immunoreactive cells and its gray value in the molecular layer, Purkinje layer and granular layer were counted respectively with Image-Pro Express Software 5.1. Compared with young cats, the density and average grey value of Glu immunoreactive cells increased significantly in the Purkinje and granular layer of old cats (P﹤0.01). The density and intensity of GABA immunoreactive neurons declined significantly in the molecular and Purkinje layers of old cats (P﹤0.01). The density of GABA immunoreactive neurons showed no evident differences in the granular layer between young and old cats (P﹥0.05), but the intensity of GABA immunoreactive neurons was visibly weaker in the granular layer of old cats (P﹤0.01). The results indicated that changes of Glu/GABA expression in the cerebellar cortex during ageing may be one of the important factors mediating the functional degeneration of accurate timing and neurons lost in old individuals.
  • loading
  • Relative Articles

    [1] Chuan-Wang TONG, Zi-Lu WANG, Peng LI, Hui ZHU, Cui-Yun CHEN, Tian-Miao HUA. Effects of senescence on the expression of BDNF and TrkB receptor in the lateral geniculate nucleus of cats. Zoological Research, 2015, 36(1): 48-53.  doi: 10.13918/j.issn.2095-8137.2015.1.48
    [2] Peng LI, Cai-Hong JIN, San JIANG, Miao-Miao LI, Zi-Lu WANG, Hui ZHU, Cui-Yun CHEN, Tian-Miao HUA. Effects of surround suppression on response adaptation of V1 neurons to visual stimuli. Zoological Research, 2014, 35(5): 411-419.  doi: 10.13918/j.issn.2095-8137.2014.5.411
    [3] Ke WANG, Hui ZHU, Cui-Yun CHEN, Peng LI, Cai-Hong JIN, Zi-Lu WANG, San JIANG, Tian-Miao HUA. Effects of ketamine and urethane on stimulation-induced c-fos expression in neurons of cat visual cortex. Zoological Research, 2013, 34(6): 582-588.  doi: 10.11813/j.issn.0254-5853.2013.6.0582
    [4] Rui-Long LIU, Ke WANG, Jian-Jun MENG, Tian-Miao HUA, Zhen LIANG, Min-Min XI. Adaptation to visual stimulation modifies the burst firing property of V1 neurons. Zoological Research, 2013, 34(E3): 245101.  doi: 10.11813/j.issn.0254-5853.2013.E3.E101
    [5] Zhiheng GOU, Xiao WANG, Wen WANG. Evolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors. Zoological Research, 2012, 33(E5-6): 75-81.  doi: 10.3724/SP.J.1141.2012.E05-06E75
    [6] SONG Hai-Yan, LIU Zai-Qun, ZHENG Lei. Expression of IFN-γ, IL-1α, NGF-β and TNF-α during the development of cerebellar cortex of Western Anhui white goose. Zoological Research, 2012, (2): 211-217.  doi: 10.3724/SP.J.1141.2012.02211
    [7] GU Chao-Yang, AN Shu-Cheng. Rat orbital frontal (orbital frontal cortex, OFC) GABA B receptor mechanisms in stress and depression. Zoological Research, 2011, 32(3): 329-336.  doi: 10.3724/SP.J.1141.2011.03329
    [8] HUA Tian-Miao *, WANG Zhen-Hua, XU Jin-Wang, DIAO Jian-Gang. Contrast Detection Learning Improves Visual Contrast Sensitivity of Cat. Zoological Research, 2010, 31(2): 155-162.  doi: 10.3724/SP.J.1141.2010.02155
    [9] DIAO Jian-gang, XU Jin-wang, LI Gu-zhou, TANG Chuan-hong, HUA Tian-miao. Age-related Changes of Glu/GABA Expression in the Primary Visual Cortex of Cat. Zoological Research, 2009, 30(1): 38-44.  doi: 10.3724/SP.J.1141.2009.01038
    [10] HE Ying-ying, LIU Shu-bai, QIAN Jin-qiao, LEE Wen-hui, ZHANG Yun. Mechanism of -CAT Cell Nuclear Transportation andSelectively Killing of Tumor cells. Zoological Research, 2008, 29(4): 386-398.  doi: 10.3724/SP.J.1141.2008.04386
    [11] HUA Tian-miao *, WAN An, WANG She-yan, MEI Bin, SUN Qing-yan. Perceptual Learning of Grate Orientation Discrimination in Cats(in English). Zoological Research, 2007, 28(1): 95-100.
    [12] ZHU Zai-man, ZHANG Chang-zheng, LUO Xun, SUN Qing-yan, MEI Bin, HUA Tian-miao. Age-related Morphological Changes in the White Matter of Cat Lumbar Spinal Cord. Zoological Research, 2005, 26(5): 527-533.
    [13] SUN Qing-yan, MEI Bin, WANG Hai-tao, ZHU Zai-man, ZHANG Chang-zheng, LUO Xun et al.. Age-related Morphological Changes in the Retina of Cat. Zoological Research, 2004, 25(6): 538-542.
    [14] LI Guang-Peng, LIAN Li, LIAN Ying, CHEN Da-Yuan. Reproduction Engineering of Domestic Cat and Nondomestic Felid Species. Zoological Research, 2001, 22(5): 413-420.
    [15] ZHANG Kun, YU Hong-bo, SHOU Tian-de. Progress in Visual Cortical Research Using Optical Imaging Based on Intrinsic Signals. Zoological Research, 2000, 21(1): 7-11.
    [16] CHEN Rong, WANG Bin. Study of Electrical Activity of the Cerebellar Cortical Purkinje Cells in the Pigeon. Zoological Research, 1999, 20(3): 239-240.
    [17] LIU Yan, LIU Wei-quan, MENG Pei-yun, JIN Ning-yi, HAN Hui-min et al.. Intaking and Transmission of Injected CAT Gene by Housefly Eggs. Zoological Research, 1998, 19(3): 250-253.
    [18] CHEN Zhong, LU Qin, YE Shi-ming, ZHU Jian-qin. The Regulation of GABA on Development of GABA Receptors in Embryonic Mice Cerebral Cortex. Zoological Research, 1997, 18(3): 299-304.
    [19] WANG Jian-jun, WU Jin-zi, ZHANG Min-yue, CHEN Jun, CHEN Wen-yan, YU Qi-xiang. Influence of Dorsal Raphe Nucleus on Electrical Activity of the Cerebellar Purkinje Cell in The Cat. Zoological Research, 1992, 13(4): 361-367.
    [20] LIU Da-kun et al.. Preliminary Observation of Mitosis in the Cerebellar Cortex Nerve Cell of Rabbit Under Experimental Injury. Zoological Research, 1985, 6(zk): 145-148.
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2438) PDF downloads(2737) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint