Volume 19 Issue 2
Mar.  1998
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ZHANG Zi-gui, DU Hong-yan, ZHANG Wei-nin, WU Fu-mei. Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters. Zoological Research, 1998, 19(2): 120-124.
Citation: ZHANG Zi-gui, DU Hong-yan, ZHANG Wei-nin, WU Fu-mei. Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters. Zoological Research, 1998, 19(2): 120-124.

Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1998-04-22
  • In this study,the effect of high Ca[2+] level by injecting CaCl[2] into bilateral hippocampus on the learning and memory behavior of young mice was investigated,and the synaptic structural parameters in the hippocampal CA[3] area were quantitatively analysed.The main results were as follow,compared with control:(1) The STL(step-through latency)of CaCl[2] group was shortened in one trial passive avoidance response,and the descrimination learning capacity of CaCl[2] group in Y-maze was greatly attenuated (P<0.01),showing the severe impairment of learning and memory in this group.(2) The thickness of post-synaptic density (PSD)of CaCl[2] group was thinned significantly (P<0.001),while the width of synaptic cleft of this group was apparently increased (P<0.05).These results suggested that the learning and memory dysfunction caused by over-loaded calcium ions in hippocampus might based on the morphological changes of the synaptic interface stucture.
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