Volume 36 Issue 2
Mar.  2015
Turn off MathJax
Article Contents

Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.
Citation: Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.

Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice

Funds:  This study was supported by the National Natural Science Foundation of China (31260513); the National Innovation Experiment Program for University Students (XJCX-2014-106)
More Information
  • Corresponding author: Jian-Li WANG
  • Received Date: 2014-09-28
  • Rev Recd Date: 2014-12-12
  • Publish Date: 2015-03-08
  • Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sex-related behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days (twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the same-sex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and self-grooming behaviors in females; in contrast, these effects were not found in males. These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males.
  • 加载中
  • [1] An XL, Zou JX, Wu RY, Yang Y, Tai FD, Zeng SY, Jia R, Zhang X, Liu EQ, Broders H. 2011. Strain and sex differences in anxiety-like and social behaviors in C57BL/6J and BALB/cJ mice. Experimental Animals, 60(2): 111-123.
    [2] Anker JJ, Carroll ME. 2011. Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones. In: Neill J C, Kulkarni J. Biological Basis of Sex Differences in Psychopharmacology. Current Topics in Behavioral Neurosciences, 8: 73-96.
    [3] Aoki M, Shimozuru M, Kikusui T, Takeuchi Y, Mori Y. 2010. Sex differences in behavioral and corticosterone responses to mild stressors in ICR mice are altered by ovariectomy in peripubertal period. Zoological Science, 27(10): 783-789.
    [4] Becker JB, Hu M. 2008. Sex differences in drug abuse. Frontiers in Neuroendocrinology, 29(1): 36-47.
    [5] Belzung C, Barreau S. 2000. Differences in drug-induced place conditioning between BALB/c and C57Bl/6 mice. Pharmacology Biochemistry and Behavior, 65(3): 419-423.
    [6] Campbell JO, Wood RD, Spear LP. 2000. Cocaine and morphine-induced place conditioning in adolescent and adult rats. Physiology & Behavior, 68(4): 487-493.
    [7] Carey RJ, DePalma G, Damianopoulos E. 2005. Evidence for Pavlovian conditioning of cocaine-induced responses linked to emotional behavioral effects. Pharmacology Biochemistry and Behavior, 80(1): 123-134.
    [8] Carroll ME, Anker JJ. 2010. Sex differences and ovarian hormones in animal models of drug dependence. Hormones and Behavior, 58(1): 44-56.
    [9] Cole SL, Hofford RS, Evert DJ, Wellman PJ, Eitan S. 2013. Social influences on morphine conditioned place preference in adolescent mice. Addiction Biology, 18(2): 274-285.
    [10] Cunningham CL, Niehus DR, Malott DH, Prather LK. 1992. Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology, 107(2-3): 385-393.
    [11] Curtis JT, Wang Z. 2007. Amphetamine effects in microtine rodents: a comparative study using monogamous and promiscuous vole species. Neuroscience, 148(4): 857-866.
    [12] Dell'omo G, Laviola G, Chiarotti F, Alleva E, Bignami G. 1993. Prenatal oxazepam effects on cocaine conditioned place preference in developing mice. Neurotoxicology and Teratology, 15(3): 207-210.
    [13] Edsbagge J, Zhu SW, Xiao MY, Wigström H, Mohammed AH, Semb H. 2004. Expression of dominant negative cadherin in the adult mouse brain modifies rearing behavior. Molecular and Cellular Neuroscience, 25(3): 524-535.
    [14] Eisener-Dorman AF, Grabowski-Boase L, Tarantino LM. 2011. Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice. Behavioral and Brain Functions, 7(1): 29.
    [15] Fiore L, Ratti G. 2007. Remote laboratory and animal behaviour: an interactive open field system. Computers & Education, 49(4): 1299-1307.
    [16] Francès H1, Graulet A, Debray M, Coudereau JP, Guéris J, Bourre JM. 2000. Morphine-induced sensitization of locomotor activity in mice: effect of social isolation on plasma corticosterone levels. Brain Research, 860(1-2): 136-140.
    [17] Ge JF, Qi CC, Qiao JP, Wang CW, Zhou JN. 2013. Sex differences in ICR mice in the Morris water maze task. Physiological Research, 62(1): 107-117.
    [18] Grabus SD, Glowa JR, Riley AL. 2004. Morphine- and cocaine-induced c-Fos levels in Lewis and Fischer rat strains. Brain Research, 998(1): 20-28.
    [19] Holly EN, Shimamoto A, Debold JF, Miczek KA. 2012. Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of episodic social defeat stress in rats. Psychopharmacology, 224(1): 179-188.
    [20] Kennedy BC, Panksepp JB, Runckel PA, Lahvis GP. 2012. Social influences on morphine-conditioned place preference in adolescent BALB/cJ and C57BL/6J mice. Psychopharmacology, 219(3): 923-932.
    [21] Kennedy BC, Panksepp JB, Wong JC, Krause EJ, Lahvis GP. 2011. Age-dependent and strain-dependent influences of morphine on mouse social investigation behavior. Behavioural Pharmacology, 22(2): 147-159.
    [22] Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Watabe K, Kubo H, Takahashi H, Tanaka K, Nishiyama N, Takemura M. 2014. Agmatine attenuates methamphetamine-induced hyperlocomotion and stereotyped behavior in mice. Behavioural Pharmacology, 25(2): 158-165.
    [23] Li M, Fu Q, Li Y, Li SS, Xue JS, Ma SP. 2014. Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia, 98: 1-10.
    [24] Liang MK, Zhong J, Liu HX, Lopatina O, Nakada R, Yamauchi AM, Higashida H. 2014. Pairmate-dependent pup retrieval as parental behavior in male mice. Frontiers in Neuroscience, 8: 186.
    [25] Mao Yu, Yang SC, Liu C, Ma YY, Hu XT. 2011. Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice. Zoological Research, 32(6): 670-674.
    [26] Miner LL. 1997. Cocaine reward and locomotor activity in C57BL/6J and 129/SvJ inbred mice and their F1 cross. Pharmacology Biochemistry and Behavior, 58(1): 25-30.
    [27] Niigaki ST, Silva RH, Patti CL, Cunha JL, Kameda SR, Correia-Pinto JC, Takatsu-Coleman AL, Levin R, Abílio VC, Frussa-Filho R. 2010. Amnestic effect of cocaine after the termination of its stimulant action. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(1): 212-218.
    [28] Niu HC, Zheng YW, Huma T, Rizak JD, Li L, Wang GM, Ren H, Xu LQ, Yang JZ, Ma YY, Lei H. 2013. Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice. Pharmacology Biochemistry and Behavior, 103(3): 526-534.
    [29] Nocjar C, Panksepp J. 2007. Prior morphine experience induces long-term increases in social interest and in appetitive behavior for natural reward. Behavioural Brain Research, 181(2): 191-199.
    [30] Orsini C, Bonito-Oliva A, Conversi D, Cabib S. 2005. Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. Psychopharmacology, 181(2): 327-336.
    [31] Perrine SA, Sheikh IS, Nwaneshiudu CA, Schroeder JA, Unterwald EM. 2008. Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat. Neuropharmacology, 54(2): 355-364.
    [32] Phillips TJ, Kamens HM, Wheeler JM. 2008. Behavioral genetic contributions to the study of addiction-related amphetamine effects. Neuroscience & Biobehavioral Reviews, 32(4): 707-759.
    [33] Shi JW, Zou H, Jin ML. 2008. Assessing exploratory behavior and memory in ICR, BALB/c and C57BL/6 mice using habituation. Zoological Research, 29(1): 49-55.
    [34] Stewart J, Badiani A. 1993. Tolerance and sensitization to the behavioral effects of drugs. Behavioural Pharmacology, 4(4): 289-312.
    [35] To CT, Bagdy G. 1999. Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. Neuropharmacology 38(2): 279-282.
    [36] Vanderschuren LJMJ, Spruijt BM, Van Ree JM, Niesink RJM. 1995. Effects of morphine on different aspects of social play in juvenile rats. Psychopharmacology, 117(2): 225-231.
    [37] Wang JL, Wang B, Chen W. 2014. Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice. Zoological Research, 35(5): 426-435.
    [38] Wang YC, Wang CC, Lee CC, Huang AC. 2010. Effects of single and group housing conditions and alterations in social and physical contexts on amphetamine-induced behavioral sensitization in rats. Neuroscience Letters, 486(1): 34-37.
    [39] Wang JL, Zhang LX, Zhang P, Tai FD. 2012. Cocaine-induced rewarding properties, behavioural sensitization and alteration in social behaviours in group-housed and postpuberty isolated female mandarin voles. Behavioural Pharmacology, 23(7): 693-702.
    [40] Xu ZW, Hou B, Gao Y, He FC, Zhang CG. 2007. Effects of enriched environment on morphine-induced reward in mice. Experimental Neurology, 204(2): 714-719.
    [41] Xu YF, Su RB, Yang RF, Wu N, Lu XQ, Li J. 2009. Effects of Y-IP5 on morphine-induced behavioral sensitization and conditioned place preference in mice. Chinese Pharmacological Bulletin, 25(12): 1578-1583.
    [42] Yamaura K, Bi Y, Ishiwatari M, Oishi N, Fukata H, Ueno K. 2013. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological Science, 30(12): 1019-1024.
    [43] Zhang Y, Mantsch JR, Schlussman SD, Ho A, Kreek MJ. 2002. Conditioned place preference after single doses or "binge" cocaine in C57BL/6J and 129/J mice. Pharmacology Biochemistry and Behavior, 73(3): 655-662.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(524) PDF downloads(1066) Cited by()

Related
Proportional views

Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice

Funds:  This study was supported by the National Natural Science Foundation of China (31260513); the National Innovation Experiment Program for University Students (XJCX-2014-106)
    Corresponding author: Jian-Li WANG

Abstract: Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sex-related behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days (twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the same-sex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and self-grooming behaviors in females; in contrast, these effects were not found in males. These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males.

Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.
Citation: Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.
Reference (43)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return