Volume 16 Issue 4
Jul.  1995
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WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.
Citation: WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.

Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1995-11-22
  • In this experiment,the synaptosomal free calcium concentration and synaptosomal membrane protein-bound Ca[2+] in various brain regions were measured by using fluorescence indicator Fura-2/AM and Tb[3+] respectively.Compared with that of 3-month-old rats,the synaptosomal free calcium concentration significantly increased in hippocampus,cerebral cortex and hypothalamus of 26-month-old rats.Moreover,the synaptosomal membrane protein-bound Ca[2+] obviously increased in hippocampus and cerebellum while in the other brain areas examined (cerebral cortex,hypothalamus) decreased significantly.These suggest that the perturbation of normal Ca[2+] homeostasis appears to be an important factor correlated with aging.
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Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions

Abstract: In this experiment,the synaptosomal free calcium concentration and synaptosomal membrane protein-bound Ca[2+] in various brain regions were measured by using fluorescence indicator Fura-2/AM and Tb[3+] respectively.Compared with that of 3-month-old rats,the synaptosomal free calcium concentration significantly increased in hippocampus,cerebral cortex and hypothalamus of 26-month-old rats.Moreover,the synaptosomal membrane protein-bound Ca[2+] obviously increased in hippocampus and cerebellum while in the other brain areas examined (cerebral cortex,hypothalamus) decreased significantly.These suggest that the perturbation of normal Ca[2+] homeostasis appears to be an important factor correlated with aging.

WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.
Citation: WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.

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