Volume 28 Issue 5
Sep.  2007
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New Proof for Astrocytes Having L-type Calcium Channels. Zoological Research, 2007, 28(5): 485-490.
Citation: New Proof for Astrocytes Having L-type Calcium Channels. Zoological Research, 2007, 28(5): 485-490.

New Proof for Astrocytes Having L-type Calcium Channels

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  • Corresponding author: CAI Jing-xia
  • Received Date: 2007-06-19
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2007-10-22
  • The laser scanning confocal mircroscope and fluorescence speotrophotometer were used to investigate the effects of the L-type calcium channel agonist 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl] pyridine-3- carboxylic acid ((±)-Bay K8644) and antagonist nimodipine on intra-cellular calcium concentration ([Ca2+]i ) of caltured mouse astrocyetes. Bay K8644 can evidently increase the [Ca2+]i in caltured astrocytes with the doses of 0.0001mM、0.001mM and 0.01mM, whereas nimodipine can decrease the [Ca2+]i with the dose of 0.001mM、0.01mM and 0.1mM. Nimodipine also can decrease the elevation of [Ca2+]i which was elicited by KCl .Our results suggested that the effets of L-type calcium channel agonist and antagonist on astrocye are same as neurons, it indicated that astrocytes also have L-type calcium channel.
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New Proof for Astrocytes Having L-type Calcium Channels

    Corresponding author: CAI Jing-xia

Abstract: The laser scanning confocal mircroscope and fluorescence speotrophotometer were used to investigate the effects of the L-type calcium channel agonist 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl] pyridine-3- carboxylic acid ((±)-Bay K8644) and antagonist nimodipine on intra-cellular calcium concentration ([Ca2+]i ) of caltured mouse astrocyetes. Bay K8644 can evidently increase the [Ca2+]i in caltured astrocytes with the doses of 0.0001mM、0.001mM and 0.01mM, whereas nimodipine can decrease the [Ca2+]i with the dose of 0.001mM、0.01mM and 0.1mM. Nimodipine also can decrease the elevation of [Ca2+]i which was elicited by KCl .Our results suggested that the effets of L-type calcium channel agonist and antagonist on astrocye are same as neurons, it indicated that astrocytes also have L-type calcium channel.

New Proof for Astrocytes Having L-type Calcium Channels. Zoological Research, 2007, 28(5): 485-490.
Citation: New Proof for Astrocytes Having L-type Calcium Channels. Zoological Research, 2007, 28(5): 485-490.

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