Volume 13 Issue 2
Mar.  1992
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XU Xiang-gui, ZHU Jian-qin, WANG Xue-qin. Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice. Zoological Research, 1992, 13(2): 139-144.
Citation: XU Xiang-gui, ZHU Jian-qin, WANG Xue-qin. Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice. Zoological Research, 1992, 13(2): 139-144.

Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1992-05-22
  • Intracerebroventricularly (I.c.v.) administered GABA (2.4.6 umol) significantly accelerated the development of gastric ulcer induced by ethanol (o.p.) in mice in a dose dependent manner,whereas GABA (I.p.100 umol) could not modify the ethanol-induced ulcer in mice.Atropine (s.e.0.2 mg/kg) exacerbated the ethanol-induced ulcer significantly,while blocking the exacerbation of ulcer induced by GABA partly.Regetine (I.m.2.5 mg/kg) potentiated the ethanol-induced ulcer weakly,and had no effect on the exacerbation of ulcer induced by GABA.These results suggested that exsragenetic GABA exacerbates the ethanolinduced gastric ulcer through central GABA-ergic mechanisms,but not peripherally.Vagus may contribute to gastric protective effect against ulceration.It may be one of main pathway in GABA s action.Sympathetic nerve maybe have relationship with the GABA-ergic mechanisms.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice

Abstract: Intracerebroventricularly (I.c.v.) administered GABA (2.4.6 umol) significantly accelerated the development of gastric ulcer induced by ethanol (o.p.) in mice in a dose dependent manner,whereas GABA (I.p.100 umol) could not modify the ethanol-induced ulcer in mice.Atropine (s.e.0.2 mg/kg) exacerbated the ethanol-induced ulcer significantly,while blocking the exacerbation of ulcer induced by GABA partly.Regetine (I.m.2.5 mg/kg) potentiated the ethanol-induced ulcer weakly,and had no effect on the exacerbation of ulcer induced by GABA.These results suggested that exsragenetic GABA exacerbates the ethanolinduced gastric ulcer through central GABA-ergic mechanisms,but not peripherally.Vagus may contribute to gastric protective effect against ulceration.It may be one of main pathway in GABA s action.Sympathetic nerve maybe have relationship with the GABA-ergic mechanisms.

XU Xiang-gui, ZHU Jian-qin, WANG Xue-qin. Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice. Zoological Research, 1992, 13(2): 139-144.
Citation: XU Xiang-gui, ZHU Jian-qin, WANG Xue-qin. Effect of Intracerebroventricular Injection of GABA on Ethanol-Induced Gastric Ulcer in Mice. Zoological Research, 1992, 13(2): 139-144.

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