Volume 25 Issue 2
Mar.  2004
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ZHAO Tong-biao, ZHAO Xin-quan, CHANG Zhi-jie, SUN Ping, XU Shi-xiao, ZHAO Wei. Tissue Specific Expression of Plateau Pikas (Ochotona curzoniae) HIF-1α mRNA Under Normal Oxygen. Zoological Research, 2004, 25(2): 132-136.
Citation: ZHAO Tong-biao, ZHAO Xin-quan, CHANG Zhi-jie, SUN Ping, XU Shi-xiao, ZHAO Wei. Tissue Specific Expression of Plateau Pikas (Ochotona curzoniae) HIF-1α mRNA Under Normal Oxygen. Zoological Research, 2004, 25(2): 132-136.

Tissue Specific Expression of Plateau Pikas (Ochotona curzoniae) HIF-1α mRNA Under Normal Oxygen

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2004-04-22
  • Hypoxia inducible factor 1 (HIF-1),which is a transcription factor composed of HIF-1α and arylhydocarbon nuclear receptor translocator (ARNT),plays an important role in the signal transduction of cell response to hypoxia.Plateau pikas (Ochotona curzoniae),which are a kind of high anoxia-tolerance and cold adaptation species lived only above 3000 m on Qinhai-Tibet Plateau,have unusual high RMR and NST,acting mainly via increasing NST to adapt to extreme cold of the Qinghai-Tibet Plateau;and high ratio of oxygen utilizing to cope with plateau hypoxia environment.In this study,the plateau pikas were taken to Beijing and adapted under normal oxygen and room temperature for 7 days.One fragment of the plateau pika HIF-1α cDNA was obtained by RT-PCR technique and labeled with [32]P as specific probe.Northern blot analysis showed that HIF-1α mRNA was expressed in many kinds of tissues and displayed a tissue specific expression:the highest in brain,next in kidney,and much less in heart,liver,and spleen.
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