Jing WANG, Xin-Li XU, Ze-Yang DING, Rong-Rong MAO, Qi-Xin ZHOU, Long-Bao LÜ, Li-Ping WANG, Shuang WANG, Chen ZHANG, Lin XU, Yue-Xiong YANG. Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis). Zoological Research, 2013, 34(E2): 13369-E. doi: 10.3724/SP.J.1141.2013.E02E69
Citation: Jing WANG, Xin-Li XU, Ze-Yang DING, Rong-Rong MAO, Qi-Xin ZHOU, Long-Bao LÜ, Li-Ping WANG, Shuang WANG, Chen ZHANG, Lin XU, Yue-Xiong YANG. Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis). Zoological Research, 2013, 34(E2): 13369-E. doi: 10.3724/SP.J.1141.2013.E02E69

Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis)

doi: 10.3724/SP.J.1141.2013.E02E69
  • Received Date: 2012-12-11
  • Rev Recd Date: 2013-02-06
  • Publish Date: 2013-04-08
  • Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational medicine. Multifold advantages such as simplicity of breeding, low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model proxy. Additional features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human diseases. However, basal physiological indexes of tree shrew, especially those related to human disease, have not been systematically reported. Accordingly, we established important basal physiological indexes of domesticated tree shrews including several factors: (1) body weight, (2) core body temperature and rhythm, (3) diet metabolism, (4) locomotor rhythm, (5) electroencephalogram, (6) glycometabolism and (7) serum and urinary hormone level and urinary cortisol rhythm. We compared the physiological parameters of domesticated tree shrew with that of rats and macaques. Results showed that (a) the core body temperature of the tree shrew was 39.59±0.05 ℃, which was higher than that of rats and macaques; (b) Compared with wild tree shrews, with two activity peaks, domesticated tree shrews had only one activity peak from 17:30 to 19:30; (c) Compared with rats, tree shrews had poor carbohydrate metabolism ability; and (d) Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews, which matched activity peaks in wild tree shrews. These results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.
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  • [1]
    Cao J, Yang EB, Su JJ, Li Y, Chow P. 2003. The tree shrews: adjuncts and alternatives to primates as models for biomedical research. Journal of Medical Primatology, 32(3): 123-130.
    [2]
    Carter AM. 2007. Animal models of human placentation—a review. Placenta, 28: S41-S47.
    [3]
    Coolen A, Hoffmann K, Barf RP, Fuchs E, Meerlo P. 2012. Telemetric study of sleep architecture and sleep homeostasis in the day-active tree shrew Tupaia belangeri. Sleep, 35(6): 879-888.
    [4]
    Elliot O. 1971. Bibliography of the tree shrews 1780-1969. Primates, 12(3-4): 323-414.
    [5]
    Fan LH, Li D, Liu ML, Fan PH. 2012. Investingation on normal reference range and values of blood physiological and biochemical indexes in clean SD rat. National Medical Frontiers of China, 6(19): 33-34. (in Chinese)
    [6]
    Fuchs E. 2005. Social stress in tree shrews as an animal model of depression: An example of a behavioral model of a CNS disorder. CNS Spectrums, 10(3): 182-190.
    [7]
    Fuchs E, Corbach-Söhle S. 2010. Tree Shrew // Hubrecht R, Kirkwood J. The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition. Singapore: Robert Hubrecht and James Kirkwood, 262-275.
    [8]
    Jane?ka JE, Miller W, Pringle TH, Wiens F, Zitzmann A, Helgen KM, Springer MS, Murphy WJ. 2007. Molecular and genomic data identify the closest living relative of primates. Science, 318(5851): 792-794.
    [9]
    Li HS, Deng X, Luo D, Zhang XF, Li S, Wang Y. 2011. Effect of angiotensin II on heart rate and heart rate variability of rat. Progress of Anatomical Sciences, 17(4): 364-367. (in Chinese)
    [10]
    Liang B, Wu XY. 2011. Progress on nonhuman primate models of diabetes mellitus. Zoological Research, 32(1): 91-96.
    [11]
    Liu W, Qian LJ, Yang ZH, Zhan R, Feng H, Wu L. 2006. The study of neuroendocrine mechanism of depression induced by chronic mild stress. Chinese Journal of Applied Physiology, 22(2): 169-172. (in Chinese)
    [12]
    Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. 2013. Dopamine neurons modulate neural encoding and expression of depression-related behavior. Nature, 493(7433): 537-541.
    [13]
    Wang J, Zhou QX, Tian M, Yang YX, Xu L. 2011. Tree shrew models: a chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 32(1): 24-30.
    [14]
    Wang J, Zhou QX, Lv LB, Xu L, Yang YX. 2012. A depression model of social defeat etiology using tree shrews. Zoological Research, 33(1): 92-98. (in Chinese)
    [15]
    Xu LJ, Tang XL, Jiu T, Chen FY. 2007. Biological indicators measurement in laboratory macaques. Laboratory Animal and Comparative Medicine, 27(1): 53-56. (in Chinese)
    [16]
    Xu M, Yu L, Ding YY, Wang YM, Wang SW, Pei JM. 2006. Experimental study on hypotensive effects of cinnamaldehyde in anesthetized rats. Chinese Heart Journal, 18(3): 272-276. (in Chinese)
    [17]
    Yu XK, Shi WZ, Zuo Q, Sun QW, Lu AY. 2006. Effects of exercise on the action scores and plasma adrenocorticotropin and corticosterone in rats under psychological stress. Chinese Journal of Sports Medicine, 25(1): 41-45. (in Chinese)
    [18]
    Zhang LY, Jiang Y, Tian BP, Ma YY, Wang GL. 1998. Study on anti-psychological stress of different drugs in macaca mulutta. Journal of Yunnan University (Natural Sciences), 20(3): 197-199.
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